WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530549
CAS#: 315698-36-3
Description: MLS1547 is a highly efficacious D2 dopamine receptor (D2R) G protein-biased agonist that does not recruit β-arrestin, and is an antagonist of dopamine-stimulated β-arrestin recruitment to the D2 receptor.
MedKoo Cat#: 530549
Name: MLS1547
CAS#: 315698-36-3
Chemical Formula: C19H19ClN4O
Exact Mass: 354.1247
Molecular Weight: 354.838
Elemental Analysis: C, 64.31; H, 5.40; Cl, 9.99; N, 15.79; O, 4.51
Synonym: MLS1547; MLS-1547; MLS 1547; MLS000051547.
IUPAC/Chemical Name: 5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol
InChi Key: OPEJNANYABTIGC-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H19ClN4O/c20-16-12-14(19(25)18-15(16)4-3-7-22-18)13-23-8-10-24(11-9-23)17-5-1-2-6-21-17/h1-7,12,25H,8-11,13H2
SMILES Code: OC1=C2N=CC=CC2=C(Cl)C=C1CN3CCN(C4=NC=CC=C4)CC3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
| Biological target: | MLS1547 is a highly efficacious G protein-biased dopamine D2 receptor (D2R) agonist (Ki=1.2 μM). |
| In vitro activity: | TBD |
| In vivo activity: | TBD |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 20.0 | 56.36 | |
| DMF:PBS (pH 7.2) (1:9) | 0.1 | 0.28 | |
| DMSO | 26.27 | 74.03 | |
| Ethanol | 5.0 | 14.09 |
The following data is based on the product molecular weight 354.838 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | TBD |
| In vitro protocol: | TBD |
| In vivo protocol: | TBD |
1: Free RB, Chun LS, Moritz AE, Miller BN, Doyle TB, Conroy JL, Padron A, Meade
JA, Xiao J, Hu X, Dulcey AE, Han Y, Duan L, Titus S, Bryant-Genevier M, Barnaeva
E, Ferrer M, Javitch JA, Beuming T, Shi L, Southall NT, Marugan JJ, Sibley DR.
Discovery and characterization of a G protein-biased agonist that inhibits
β-arrestin recruitment to the D2 dopamine receptor. Mol Pharmacol. 2014
Jul;86(1):96-105. doi: 10.1124/mol.113.090563. PubMed PMID: 24755247; PubMed
Central PMCID: PMC4054005.
