WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530549

CAS#: 315698-36-3

Description: MLS1547 is a highly efficacious D2 dopamine receptor (D2R) G protein-biased agonist that does not recruit β-arrestin, and is an antagonist of dopamine-stimulated β-arrestin recruitment to the D2 receptor.

Chemical Structure

CAS# 315698-36-3

Theoretical Analysis

MedKoo Cat#: 530549
Name: MLS1547
CAS#: 315698-36-3
Chemical Formula: C19H19ClN4O
Exact Mass: 354.1247
Molecular Weight: 354.838
Elemental Analysis: C, 64.31; H, 5.40; Cl, 9.99; N, 15.79; O, 4.51

Price and Availability

Size Price Availability Quantity
50.0mg USD 450.0 2 Weeks
100.0mg USD 750.0 2 Weeks
200.0mg USD 1250.0 2 Weeks
500.0mg USD 2650.0 2 Weeks
1.0g USD 3850.0 2 Weeks
2.0g USD 6450.0 2 Weeks
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Synonym: MLS1547; MLS-1547; MLS 1547; MLS000051547.

IUPAC/Chemical Name: 5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol


InChi Code: InChI=1S/C19H19ClN4O/c20-16-12-14(19(25)18-15(16)4-3-7-22-18)13-23-8-10-24(11-9-23)17-5-1-2-6-21-17/h1-7,12,25H,8-11,13H2


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Biological target: MLS1547 is a highly efficacious G protein-biased dopamine D2 receptor (D2R) agonist (Ki=1.2 μM).
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMF 20.0 56.36
DMF:PBS (pH 7.2) (1:9) 0.1 0.28
DMSO 26.27 74.03
Ethanol 5.0 14.09

Preparing Stock Solutions

The following data is based on the product molecular weight 354.838 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Free RB, Chun LS, Moritz AE, Miller BN, Doyle TB, Conroy JL, Padron A, Meade
JA, Xiao J, Hu X, Dulcey AE, Han Y, Duan L, Titus S, Bryant-Genevier M, Barnaeva
E, Ferrer M, Javitch JA, Beuming T, Shi L, Southall NT, Marugan JJ, Sibley DR.
Discovery and characterization of a G protein-biased agonist that inhibits
β-arrestin recruitment to the D2 dopamine receptor. Mol Pharmacol. 2014
Jul;86(1):96-105. doi: 10.1124/mol.113.090563. PubMed PMID: 24755247; PubMed
Central PMCID: PMC4054005.


50.0mg / USD 450.0