MA-2029
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532174

CAS#: 287206-61-5

Description: MA-2029 is a novel selective and competitive motilin receptor antagonist. It inhibits motilin-induced intestinal contractions and visceral pain in rabbits.


Chemical Structure

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MA-2029
CAS# 287206-61-5

Theoretical Analysis

MedKoo Cat#: 532174
Name: MA-2029
CAS#: 287206-61-5
Chemical Formula: C31H46ClFN4O4
Exact Mass: 592.3192
Molecular Weight: 593.1814
Elemental Analysis: C, 62.77; H, 7.82; Cl, 5.98; F, 3.20; N, 9.45; O, 10.79

Price and Availability

Size Price Availability Quantity
10.0mg USD 385.0 2 Weeks
50.0mg USD 1305.0 2 Weeks
Bulk inquiry

Synonym: MA-2029; MA 2029; MA2029.

IUPAC/Chemical Name: (2S)-N-[(2S)-3-(3-tert-butyl-4-hydroxyphenyl)-1-(ethylamino)-1-oxopropan-2-yl]-2-[[(2S)-3-(4-fluorophenyl)-2-(methylamino)propanoyl]-methylamino]-3-methylbutanamide;hydrochloride

InChi Key: AMSDRHOIAWZBTJ-PBQYMGKRSA-N

InChi Code: InChI=1S/C31H45FN4O4.ClH/c1-9-34-28(38)24(18-21-12-15-26(37)23(16-21)31(4,5)6)35-29(39)27(19(2)3)36(8)30(40)25(33-7)17-20-10-13-22(32)14-11-20;/h10-16,19,24-25,27,33,37H,9,17-18H2,1-8H3,(H,34,38)(H,35,39);1H/t24-,25-,27-;/m0./s1

SMILES Code: CC(C)[C@H](N(C([C@@H](NC)CC1=CC=C(F)C=C1)=O)C)C(N[C@@H](CC2=CC=C(O)C(C(C)(C)C)=C2)C(NCC)=O)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 593.1814 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Mondal A, Koyama K, Mikami T, Horita T, Takemi S, Tsuda S, Sakata I, Sakai T. Underlying mechanism of the cyclic migrating motor complex in Suncus murinus: a change in gastrointestinal pH is the key regulator. Physiol Rep. 2017 Jan;5(1). pii: e13105. doi: 10.14814/phy2.13105. PubMed PMID: 28082431; PubMed Central PMCID: PMC5256163.

2: Kuroda K, Hequing H, Mondal A, Yoshimura M, Ito K, Mikami T, Takemi S, Jogahara T, Sakata I, Sakai T. Ghrelin Is an Essential Factor for Motilin-Induced Gastric Contraction in Suncus murinus. Endocrinology. 2015 Dec;156(12):4437-47. doi: 10.1210/en.2015-1561. PubMed PMID: 26441238.

3: Mondal A, Xie Z, Miyano Y, Tsutsui C, Sakata I, Kawamoto Y, Aizawa S, Tanaka T, Oda S, Sakai T. Coordination of motilin and ghrelin regulates the migrating motor complex of gastrointestinal motility in Suncus murinus. Am J Physiol Gastrointest Liver Physiol. 2012 May 15;302(10):G1207-15. doi: 10.1152/ajpgi.00379.2011. PubMed PMID: 22383491.

4: Ozaki K, Onoma M, Muramatsu H, Sudo H, Yoshida S, Shiokawa R, Yogo K, Kamei K, Cynshi O, Kuromaru O, Peeters TL, Takanashi H. An orally active motilin receptor antagonist, MA-2029, inhibits motilin-induced gastrointestinal motility, increase in fundic tone, and diarrhea in conscious dogs without affecting gastric emptying. Eur J Pharmacol. 2009 Aug 1;615(1-3):185-92. doi: 10.1016/j.ejphar.2009.04.059. PubMed PMID: 19445919.

5: Tabo M, Komatsu R, Honda M, Itoh M, Kimura K. Cardiovascular safety profile of MA-2029, a novel motilin receptor antagonist. J Toxicol Sci. 2008 Dec;33(5):631-9. PubMed PMID: 19043284.

6: Sudo H, Yoshida S, Ozaki K, Muramatsu H, Onoma M, Yogo K, Kamei K, Cynshi O, Kuromaru O, Peeters TL, Takanashi H. Oral administration of MA-2029, a novel selective and competitive motilin receptor antagonist, inhibits motilin-induced intestinal contractions and visceral pain in rabbits. Eur J Pharmacol. 2008 Mar 10;581(3):296-305. doi: 10.1016/j.ejphar.2007.11.049. PubMed PMID: 18164286.

7: Mitselos A, Depoortere I, Peeters TL. Delineation of the motilin domain involved in desensitization and internalization of the motilin receptor by using full and partial antagonists. Biochem Pharmacol. 2007 Jan 1;73(1):115-24. PubMed PMID: 17074305.

MA-2029

10.0mg / USD 385.0