LY367385 HCl
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MedKoo CAT#: 532163

CAS#: 2829282-00-8

Description: LY367385 is a selective mGlu1a receptor antagonist, with an IC50 value of 8.8 μM for blockade of quisqualate-induced phosphoinositide hydrolysis.


Chemical Structure

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LY367385 HCl
CAS# 2829282-00-8

Theoretical Analysis

MedKoo Cat#: 532163
Name: LY367385 HCl
CAS#: 2829282-00-8
Chemical Formula: C10H12ClNO4
Exact Mass: 209.07
Molecular Weight: 245.659
Elemental Analysis: C, 48.89; H, 4.92; Cl, 14.43; N, 5.70; O, 26.05

Price and Availability

Size Price Availability Quantity
5mg USD 300 2 weeks
25mg USD 800 2 weeks
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Related CAS #: 198419-91-9 (free base)   LY367385 HCl,  

Synonym: LY367385; LY 367385; LY-367385; LY367385 HCl; LY367385 hydrochloride

IUPAC/Chemical Name: 4-[(1S)-1-amino-2-hydroxy-2-oxoethyl]-3-methylbenzoic acid hydrochloride

InChi Key: IGKQWSUZDKTEPR-QRPNPIFTSA-N

InChi Code: InChI=1S/C10H11NO4.ClH/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15;/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15);1H/t8-;/m0./s1

SMILES Code: O=C(O)C1=CC=C([C@H](N)C(O)=O)C(C)=C1.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Safety Data Sheet (SDS):
Biological target: LY367385 is a selective mGlu1a receptor antagonist, with an IC50 value of 8.8 μM.
In vitro activity: TBD
In vivo activity: LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid) have been administered intracerebroventricularly (i.c.v.) to DBA/2 mice and lethargic mice (lh/lh), and focally into the inferior colliculus of genetically epilepsy prone rats (GEPR). In DBA/2 mice both compounds produce a rapid, transient suppression of sound-induced clonic seizures (LY 367385: ED50 = 12 nmol, i.c.v., 5 min; AIDA: ED50 = 79 nmol, i.c.v., 15 min). Reference: Eur J Pharmacol. 1999 Feb 26;368(1):17-24. https://pubmed.ncbi.nlm.nih.gov/10096765/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 125.0 508.84
Water 12.5 50.88

Preparing Stock Solutions

The following data is based on the product molecular weight 245.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Chapman AG, Yip PK, Yap JS, Quinn LP, Tang E, Harris JR, Meldrum BS. Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid). Eur J Pharmacol. 1999 Feb 26;368(1):17-24. doi: 10.1016/s0014-2999(99)00014-x. PMID: 10096765.
In vitro protocol: TBD
In vivo protocol: 1. Chapman AG, Yip PK, Yap JS, Quinn LP, Tang E, Harris JR, Meldrum BS. Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid). Eur J Pharmacol. 1999 Feb 26;368(1):17-24. doi: 10.1016/s0014-2999(99)00014-x. PMID: 10096765.

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