IT-901
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MedKoo CAT#: 407414

CAS#: 1584121-99-2

Description: IT-901 is a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB-Controlled Oxidative Stress Responses. IT-901 potently inhibits the NF-κB subunit c-Rel. IT-901 suppressed graft-versus-host disease while preserving graft-versus-lymphoma activity during allogeneic transplantation. Further preclinical assessment of IT-901 for the treatment of human B-cell lymphoma revealed antitumor properties in vitro and in vivo without restriction to NF-κB-dependent lymphoma. IT-901 did not elicit increased levels of reactive oxygen species in normal leukocytes, illustrating its cancer selective properties. IT-901 is a novel therapeutic agent to treat human lymphoid tumors and ameliorate graft-versus-host disease.


Chemical Structure

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IT-901
CAS# 1584121-99-2

Theoretical Analysis

MedKoo Cat#: 407414
Name: IT-901
CAS#: 1584121-99-2
Chemical Formula: C17H14N2O4S
Exact Mass: 342.0674
Molecular Weight: 342.369
Elemental Analysis: C, 59.64; H, 4.12; N, 8.18; O, 18.69; S, 9.36

Price and Availability

Size Price Availability Quantity
5.0mg USD 260.0 2 Weeks
10.0mg USD 420.0 2 Weeks
50.0mg USD 1200.0 2 Weeks
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Synonym: IT-901; IT 901; IT901.

IUPAC/Chemical Name: 5-[(2,4-Dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione

InChi Key: JHOPCCOYRKEHQU-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H14N2O4S/c1-22-13-8-14(23-2)11(9-5-3-4-6-10(9)13)7-12-15(20)18-17(24)19-16(12)21/h3-8H,1-2H3,(H2,18,19,20,21,24)

SMILES Code: O=C(/C(C(N1)=O)=C\C2=C3C=CC=CC3=C(OC)C=C2OC)NC1=S

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 342.369 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Shono Y, Tuckett AZ, Liou HC, Doubrovina E, Derenzini E, Ouk S, Tsai JJ, Smith
OM, Levy ER, Kreines FM, Ziegler CG, Scallion MI, Doubrovin M, Heller G, Younes
A, O'Reilly RJ, van den Brink MR, Zakrzewski JL. Characterization of a c-Rel
Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by
Blocking NF-κB-Controlled Oxidative Stress Responses. Cancer Res. 2016 Jan
15;76(2):377-89. doi: 10.1158/0008-5472.CAN-14-2814. PubMed PMID: 26744524;
PubMed Central PMCID: PMC4715937.

IT-901

5.0mg / USD 260.0