WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 532105
CAS#: 634193-54-7
Description: L-902,688 is a highly potent agonist of the human PGE2 receptor, EP4. L902688 demonstrates a Ki value of 0.38 nM and an EC50 value of 0.6 nM and is >4,000-fold selective for EP4 over other EP and prostanoid receptors. Note: This product is supplied as methanol solution
MedKoo Cat#: 532105
Name: L902688
CAS#: 634193-54-7
Chemical Formula: C21H27F2N5O2
Exact Mass: 419.2133
Molecular Weight: 419.48
Elemental Analysis: C, 60.13; H, 6.49; F, 9.06; N, 16.70; O, 7.63
Synonym: L902688; L-902688; L 902688.
IUPAC/Chemical Name: (5R)-5-[(1E,3R)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl]-1-[6-(1H-1,2,3,4-tetrazol-5-yl)hexyl]pyrrolidin-2-one
InChi Key: WPTLQOYLIXWRNN-SLKVGHROSA-N
InChi Code: InChI=1S/C21H27F2N5O2/c22-21(23,16-8-4-3-5-9-16)18(29)13-11-17-12-14-20(30)28(17)15-7-2-1-6-10-19-24-26-27-25-19/h3-5,8-9,11,13,17-18,29H,1-2,6-7,10,12,14-15H2,(H,24,25,26,27)/b13-11+/t17-,18+/m0/s1
SMILES Code: O=C1N(CCCCCCC2=NN=NN2)[C@@H](/C=C/[C@@H](O)C(F)(F)C3=CC=CC=C3)CC1
Appearance: supplied as methanol solution.
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 419.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Malty RH, Hudmon A, Fehrenbacher JC, Vasko MR. Long-term exposure to PGE2 causes homologous desensitization of receptor-mediated activation of protein kinase A. J Neuroinflammation. 2016 Jul 11;13(1):181. doi: 10.1186/s12974-016-0645-0. PubMed PMID: 27400965; PubMed Central PMCID: PMC4940832.
