MRX-I

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 529122

CAS#: 1112968-42-9

Description: MRX-I is a monoamine oxidase-A (MAO-A) Inhibitor potentially for the treatment of acute bacterial skin.


Chemical Structure

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MRX-I
CAS# 1112968-42-9

Theoretical Analysis

MedKoo Cat#: 529122
Name: MRX-I
CAS#: 1112968-42-9
Chemical Formula: C18H15F3N4O4
Exact Mass: 408.1045
Molecular Weight: 408.33
Elemental Analysis: C, 52.95; H, 3.70; F, 13.96; N, 13.72; O, 15.67

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MRX-I; MRXI; MRX I; contezolid;

IUPAC/Chemical Name: (S)-5-((isoxazol-3-ylamino)methyl)-3-(2,3,5-trifluoro-4-(4-oxo-3,4-dihydropyridin-1(2H)-yl)phenyl)oxazolidin-2-one

InChi Key: SULYVXZZUMRQAX-NSHDSACASA-N

InChi Code: InChI=1S/C18H15F3N4O4/c19-12-7-13(15(20)16(21)17(12)24-4-1-10(26)2-5-24)25-9-11(29-18(25)27)8-22-14-3-6-28-23-14/h1,3-4,6-7,11H,2,5,8-9H2,(H,22,23)/t11-/m0/s1

SMILES Code: O=C1CCN(C2=C(F)C=C(N3C(O[C@@H](CNC4=NOC=C4)C3)=O)C(F)=C2F)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 408.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Eckburg PB, Ge Y, Hafkin B. Single- and Multiple-Dose Study to Determine the Safety, Tolerability, Pharmacokinetics, and Food Effect of Oral MRX-I versus Linezolid in Healthy Adult Subjects. Antimicrob Agents Chemother. 2017 Feb 6. pii: AAC.02181-16. doi: 10.1128/AAC.02181-16. [Epub ahead of print] PubMed PMID: 28167545.

2: Meng J, Zhong D, Li L, Yuan Z, Yuan H, Xie C, Zhou J, Li C, Gordeev MF, Liu J, Chen X. Metabolism of MRX-I, a novel antibacterial oxazolidinone, in humans: the oxidative ring opening of 2,3-Dihydropyridin-4-one catalyzed by non-P450 enzymes. Drug Metab Dispos. 2015 May;43(5):646-59. doi: 10.1124/dmd.114.061747. PubMed PMID: 25710940.

3: Huang Y, Xu Y, Liu S, Wang H, Xu X, Guo Q, Wu B, Gordeev MF, Wang W, Yuan Z, Wang M. Selection and characterisation of Staphylococcus aureus mutants with reduced susceptibility to the investigational oxazolidinone MRX-I. Int J Antimicrob Agents. 2014 May;43(5):418-22. doi: 10.1016/j.ijantimicag.2014.02.008. PubMed PMID: 24721233.

4: Li CR, Zhai QQ, Wang XK, Hu XX, Li GQ, Zhang WX, Pang J, Lu X, Yuan H, Gordeev MF, Chen LT, Yang XY, You XF. In vivo antibacterial activity of MRX-I, a new oxazolidinone. Antimicrob Agents Chemother. 2014;58(4):2418-21. doi: 10.1128/AAC.01526-13. PubMed PMID: 24395231; PubMed Central PMCID: PMC4023790.

5: Gordeev MF, Yuan ZY. New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. J Med Chem. 2014 Jun 12;57(11):4487-97. doi: 10.1021/jm401931e. Review. PubMed PMID: 24694071.

6: Kern WV. [New antibacterial agents on the market and in the pipeline]. Internist (Berl). 2015 Nov;56(11):1255-63. Review. German. PubMed PMID: 26475603.