Ribociclib succinate

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MedKoo CAT#: 100948

CAS#: 1374639-75-4 (succinate)

Description: Ribociclib, also known as LEE011, is an experimental drug that is an inhibitor of cyclin D1/CDK4 and CDK6, and is being studied as a treatment for drug-resistant cancers. It was developed by Novartis and Astex Pharmaceuticals. Cyclin-dependent kinases (CDKs) 4 and 6 are enzymes that have been shown to promote cell division and multiplication in both normal and cancer cells. Many cancer cells have shown abnormalities that increase the activity of CDK, leading to the inactivation of certain tumor suppressor genes. This has led to the idea that inhibiting CDK4 will slow the growth of tumors by reactivating these tumor suppressors. When used in combination with other drugs such as an ALK or an MEK inhibitor, ribociclib has been shown to have a synergistic effect, resulting in improved responses

Chemical Structure

Ribociclib succinate
CAS# 1374639-75-4 (succinate)

Theoretical Analysis

MedKoo Cat#: 100948
Name: Ribociclib succinate
CAS#: 1374639-75-4 (succinate)
Chemical Formula: C27H36N8O5
Exact Mass:
Molecular Weight: 552.636
Elemental Analysis: C, 58.68; H, 6.57; N, 20.28; O, 14.48

Size Price Shipping out time Quantity
50mg USD 90 Same day
100mg USD 150 Same day
200mg USD 250 Same day
500mg USD 450 Same day
1g USD 750 Same day
2g USD 1250 Same day
5g USD 2450 Same day
10g USD 3850 Same day
50g USD 9850 Same day
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Pricing updated 2021-03-04. Prices are subject to change without notice.

Ribociclib succinate, purity > 98%, is in stock. The same day shipping out after order is received.

Related CAS #: 1211441-98-3 (free base)   1211443-80-9 (HCl)   1374639-75-4 (succinate)    

Synonym: Ribociclib succinate; LEE011-BBA; LEE011 succinate; LEE011; LEE-011; LEE 011; LEE011A; LEE-011A; LEE 011A; Kisqali;

IUPAC/Chemical Name: 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate


InChi Code: InChI=1S/C23H30N8O.C4H6O4/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30;5-3(6)1-2-4(7)8/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28);1-2H2,(H,5,6)(H,7,8)


Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Soluble in DMSO 100.0

Preparing Stock Solutions

The following data is based on the product molecular weight 552.636 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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