WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 532078
CAS#: 874882-93-6 (HCl)
Description: L-741,742 hydrochloride is a potent and highly selective D4 dopamine receptor antagonist, with Ki values of > 1700, 770 and 3.5 nM at cloned human D2, D3 and D4 receptors.
MedKoo Cat#: 532078
Name: L-741,742 hydrochloride
CAS#: 874882-93-6 (HCl)
Chemical Formula: C23H26Cl2N2O
Molecular Weight: 417.37
Elemental Analysis: C, 66.19; H, 6.28; Cl, 16.99; N, 6.71; O, 3.83
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 874882-93-6 (HCl) 156337-32-5 (Free Base)
Synonym: L-741,742 hydrochloride; L741742; L 741742; L-741742.
IUPAC/Chemical Name: 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole hydrochloride
InChi Key: HZRPUQURUAXOHB-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H25ClN2O.ClH/c1-17-22(25-27-23(17)20-7-9-21(24)10-8-20)19-12-15-26(16-13-19)14-11-18-5-3-2-4-6-18;/h2-10,19H,11-16H2,1H3;1H
SMILES Code: CC1=C(C2=CC=C(Cl)C=C2)ON=C1C3CCN(CCC4=CC=CC=C4)CC3.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 417.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Rowley M, Collins I, Broughton HB, Davey WB, Baker R, Emms F, Marwood R, Patel S, Patel S, Ragan CI, Freedman SB, Ball R, Leeson PD. 4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor. J Med Chem. 1997 Jul 18;40(15):2374-85. PubMed PMID: 9240352.