WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 532074
CAS#: 152885-49-9
Description: L-736380, also known as L-736,380, is a CCK-B receptor antagonist. L-736,380 dose-dependently inhibited gastric acid secretion in anesthetized rats (ID(50), 0.064 mg/kg) and ex vivo binding of [(125)I]CCK-8S in BKTO mice brain membranes (ED(50), 1.7 mg/kg) and is one of the most potent acidic CCK-B receptor antagonists yet described.
MedKoo Cat#: 532074
Name: L-736380
CAS#: 152885-49-9
Chemical Formula: C25H29N9O2
Exact Mass: 487.2444
Molecular Weight: 487.57
Elemental Analysis: C, 61.59; H, 6.00; N, 25.86; O, 6.56
This product is not in stock, which may be available by custom synthesis.
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Synonym: L-736380; L 736380; L736380; L-736,380; L 736,380; L736,380.
IUPAC/Chemical Name: 1-[(3R)-5-cyclohexyl-1-methyl-2-oxo-3H-1,4-benzodiazepin-3-yl]-3-[3-(methyl-(2H-tetrazol-5-yl)amino)phenyl]urea
InChi Key: MYPNMQPMQUAOTH-QFIPXVFZSA-N
InChi Code: InChI=1S/C25H29N9O2/c1-33(24-29-31-32-30-24)18-12-8-11-17(15-18)26-25(36)28-22-23(35)34(2)20-14-7-6-13-19(20)21(27-22)16-9-4-3-5-10-16/h6-8,11-16,22H,3-5,9-10H2,1-2H3,(H2,26,28,36)(H,29,30,31,32)/t22-/m0/s1
SMILES Code: O=C(NC1=CC=CC(N(C)C2=NNN=N2)=C1)N[C@H]3C(N(C)C4=CC=CC=C4C(C5CCCCC5)=N3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 487.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Castro JL, Ball RG, Broughton HB, Russell MG, Rathbone D, Watt AP, Baker R,
Chapman KL, Fletcher AE, Patel S, Smith AJ, Marshall GR, Ryecroft W, Matassa VG.
Controlled modification of acidity in cholecystokinin B receptor antagonists:
N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas. J Med Chem.
1996 Feb 16;39(4):842-9. PubMed PMID: 8632408.
