L690330
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532065

CAS#: 142523-38-4

Description: L690330 is a potent inhibitor of inositol monophophatase. L690330 induces autophagy in COS-7 cells independently of mTOR inhibition.


Chemical Structure

img
L690330
CAS# 142523-38-4

Theoretical Analysis

MedKoo Cat#: 532065
Name: L690330
CAS#: 142523-38-4
Chemical Formula: C8H12O8P2
Exact Mass: 298.0007
Molecular Weight: 298.12
Elemental Analysis: C, 32.23; H, 4.06; O, 42.93; P, 20.78

Price and Availability

Size Price Availability Quantity
10.0mg USD 300.0 2 Weeks
Bulk inquiry

Synonym: L690330; L 690330; L-690330.

IUPAC/Chemical Name: [1-(4-hydroxyphenoxy)-1-phosphonoethyl]phosphonic acid

InChi Key: JKOCAAWWDVHWKB-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H12O8P2/c1-8(17(10,11)12,18(13,14)15)16-7-4-2-6(9)3-5-7/h2-5,9H,1H3,(H2,10,11,12)(H2,13,14,15)

SMILES Code: CC(OC1=CC=C(O)C=C1)(P(O)(O)=O)P(O)(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 298.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Shtein L, Toker L, Bersudsky Y, Belmaker RH, Agam G. The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test. Psychopharmacology (Berl). 2013 Jun;227(3):503-8. doi: 10.1007/s00213-013-2969-0. PubMed PMID: 23344554.

2: Sarkar S, Rubinsztein DC. Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations. Autophagy. 2006 Apr-Jun;2(2):132-4. Review. PubMed PMID: 16874097.

3: Westfall TA, Hjertos B, Slusarski DC. Requirement for intracellular calcium modulation in zebrafish dorsal-ventral patterning. Dev Biol. 2003 Jul 15;259(2):380-91. PubMed PMID: 12871708.

4: Sconzo G, Cascino D, Amore G, Geraci F, Giudice G. Effect of the IMPase inhibitor L690,330 on sea urchin development. Cell Biol Int. 1998;22(2):91-4. PubMed PMID: 9878095.

5: Cui H, Meng Y, Bulleit RF. Inhibition of glycogen synthase kinase 3beta activity regulates proliferation of cultured cerebellar granule cells. Brain Res Dev Brain Res. 1998 Dec 7;111(2):177-88. PubMed PMID: 9838099.

6: Piettre SR, André C, Chanal MC, Ducep JB, Lesur B, Piriou F, Raboisson P, Rondeau JM, Schelcher C, Zimmermann P, Ganzhorn AJ. Monoaryl- and bisaryldihydroxytropolones as potent inhibitors of inositol monophosphatase. J Med Chem. 1997 Dec 19;40(26):4208-21. PubMed PMID: 9435892.

7: Slusarski DC, Corces VG, Moon RT. Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature. 1997 Nov 27;390(6658):410-3. PubMed PMID: 9389482.

8: Atack JR. Inositol monophosphatase inhibitors--lithium mimetics? Med Res Rev. 1997 Mar;17(2):215-24. Review. PubMed PMID: 9057165.

9: Atack JR, Prior AM, Fletcher SR, Quirk K, McKernan R, Ragan CI. Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers. J Pharmacol Exp Ther. 1994 Jul;270(1):70-6. PubMed PMID: 8035344.

10: Atack JR, Cook SM, Watt AP, Fletcher SR, Ragan CI. In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J Neurochem. 1993 Feb;60(2):652-8. PubMed PMID: 8380439.

L690330

10.0mg / USD 300.0