WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 532065
CAS#: 142523-38-4
Description: L690330 is a potent inhibitor of inositol monophophatase. L690330 induces autophagy in COS-7 cells independently of mTOR inhibition.
MedKoo Cat#: 532065
Name: L690330
CAS#: 142523-38-4
Chemical Formula: C8H12O8P2
Exact Mass: 298.0007
Molecular Weight: 298.12
Elemental Analysis: C, 32.23; H, 4.06; O, 42.93; P, 20.78
Synonym: L690330; L 690330; L-690330.
IUPAC/Chemical Name: [1-(4-hydroxyphenoxy)-1-phosphonoethyl]phosphonic acid
InChi Key: JKOCAAWWDVHWKB-UHFFFAOYSA-N
InChi Code: InChI=1S/C8H12O8P2/c1-8(17(10,11)12,18(13,14)15)16-7-4-2-6(9)3-5-7/h2-5,9H,1H3,(H2,10,11,12)(H2,13,14,15)
SMILES Code: CC(OC1=CC=C(O)C=C1)(P(O)(O)=O)P(O)(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 298.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Shtein L, Toker L, Bersudsky Y, Belmaker RH, Agam G. The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test. Psychopharmacology (Berl). 2013 Jun;227(3):503-8. doi: 10.1007/s00213-013-2969-0. PubMed PMID: 23344554.
2: Sarkar S, Rubinsztein DC. Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations. Autophagy. 2006 Apr-Jun;2(2):132-4. Review. PubMed PMID: 16874097.
3: Westfall TA, Hjertos B, Slusarski DC. Requirement for intracellular calcium modulation in zebrafish dorsal-ventral patterning. Dev Biol. 2003 Jul 15;259(2):380-91. PubMed PMID: 12871708.
4: Sconzo G, Cascino D, Amore G, Geraci F, Giudice G. Effect of the IMPase inhibitor L690,330 on sea urchin development. Cell Biol Int. 1998;22(2):91-4. PubMed PMID: 9878095.
5: Cui H, Meng Y, Bulleit RF. Inhibition of glycogen synthase kinase 3beta activity regulates proliferation of cultured cerebellar granule cells. Brain Res Dev Brain Res. 1998 Dec 7;111(2):177-88. PubMed PMID: 9838099.
6: Piettre SR, André C, Chanal MC, Ducep JB, Lesur B, Piriou F, Raboisson P, Rondeau JM, Schelcher C, Zimmermann P, Ganzhorn AJ. Monoaryl- and bisaryldihydroxytropolones as potent inhibitors of inositol monophosphatase. J Med Chem. 1997 Dec 19;40(26):4208-21. PubMed PMID: 9435892.
7: Slusarski DC, Corces VG, Moon RT. Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature. 1997 Nov 27;390(6658):410-3. PubMed PMID: 9389482.
8: Atack JR. Inositol monophosphatase inhibitors--lithium mimetics? Med Res Rev. 1997 Mar;17(2):215-24. Review. PubMed PMID: 9057165.
9: Atack JR, Prior AM, Fletcher SR, Quirk K, McKernan R, Ragan CI. Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers. J Pharmacol Exp Ther. 1994 Jul;270(1):70-6. PubMed PMID: 8035344.
10: Atack JR, Cook SM, Watt AP, Fletcher SR, Ragan CI. In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J Neurochem. 1993 Feb;60(2):652-8. PubMed PMID: 8380439.
