WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 528315

CAS#: 280585-34-4

Description: Oxeglitazar, also known as EMD-336340 and LM-4156, is a peroxisome proliferator-activated receptor (PPAR) agonist potentially for the treatment of gout and type two diabetes.

Chemical Structure

CAS# 280585-34-4

Theoretical Analysis

MedKoo Cat#: 528315
Name: Oxeglitazar
CAS#: 280585-34-4
Chemical Formula: C19H22O4
Exact Mass: 314.1518
Molecular Weight: 314.381
Elemental Analysis: C, 72.59; H, 7.05; O, 20.36

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Oxeglitazar; EMD-336340; EMD336340; EMD 336340; LM-4156; LM 4156; LM4156

IUPAC/Chemical Name: (2E,4E)-5-(7-methoxy-3,3-dimethyl-2,3-dihydrobenzo[b]oxepin-5-yl)-3-methylpenta-2,4-dienoic acid


InChi Code: InChI=1S/C19H22O4/c1-13(9-18(20)21)5-6-14-11-19(2,3)12-23-17-8-7-15(22-4)10-16(14)17/h5-11H,12H2,1-4H3,(H,20,21)/b6-5+,13-9+

SMILES Code: O=C(O)/C=C(C)/C=C/C1=CC(C)(C)COC2=CC=C(OC)C=C12

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 314.381 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kalivoda A, Fischbach M, Kleinebudde P. Application of mixtures of polymeric carriers for dissolution enhancement of oxeglitazar using hot-melt extrusion. Int J Pharm. 2012 Dec 15;439(1-2):145-56. doi: 10.1016/j.ijpharm.2012.10.013. PubMed PMID: 23073606.

2: Badens E, Majerik V, Horváth G, Szokonya L, Bosc N, Teillaud E, Charbit G. Comparison of solid dispersions produced by supercritical antisolvent and spray-freezing technologies. Int J Pharm. 2009 Jul 30;377(1-2):25-34. doi: 10.1016/j.ijpharm.2009.04.047. PubMed PMID: 19442711.

3: Majerik V, Horváth G, Szokonya L, Charbit G, Badens E, Bosc N, Teillaud E. Supercritical antisolvent versus coevaporation: preparation and characterization of solid dispersions. Drug Dev Ind Pharm. 2007 Sep;33(9):975-83. PubMed PMID: 17891584.