Delucemine Hydrochloride

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MedKoo CAT#: 528314

CAS#: 186495-99-8 (HCl)

Description: Delucemine Hydrochloride, also known as NPS-1506, is a glutamate receptor antagonist potentially for the treatment of major depressive disorder and stroke. Delucemine Hydrochloride is a moderate affinity antagonist that inhibits NMDA/glycine-induced increases in cytosolic calcium in cultured rat cerebellar granule cells and displaces the binding of [3H]MK-801 to rat cortical membranes. Delucemine Hydrochloride improved measures of brain tissue edema and ion homeostasis.


Chemical Structure

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Delucemine Hydrochloride
CAS# 186495-99-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 528314
Name: Delucemine Hydrochloride
CAS#: 186495-99-8 (HCl)
Chemical Formula: C16H18ClF2N
Exact Mass: 0.00
Molecular Weight: 297.774
Elemental Analysis: C, 64.54; H, 6.09; Cl, 11.91; F, 12.76; N, 4.70

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 186495-99-8 (HCl)   186495-49-8 (free),  

Synonym: Delucemine Hydrochloride; Delucemine; Delucemine HCl; NPS-1506; NPS 1506; NPS1506

IUPAC/Chemical Name: 3,3-bis(3-fluorophenyl)-N-methylpropan-1-amine hydrochloride

InChi Key: MGNMVYXIKDNAKK-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H17F2N.ClH/c1-19-9-8-16(12-4-2-6-14(17)10-12)13-5-3-7-15(18)11-13;/h2-7,10-11,16,19H,8-9H2,1H3;1H

SMILES Code: CNCCC(C1=CC=CC(F)=C1)C2=CC=CC(F)=C2.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 297.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Browne KD, Leoni MJ, Iwata A, Chen XH, Smith DH. Acute treatment with MgSO4 attenuates long-term hippocampal tissue loss after brain trauma in the rat. J Neurosci Res. 2004 Sep 15;77(6):878-83. PubMed PMID: 15334605.

2: Fuchigami T, Haradahira T, Arai T, Okauchi T, Maeda J, Suzuki K, Yamamoto F, Suhara T, Sasaki S, Maeda M. Synthesis and brain regional distribution of [11C]NPS 1506 in mice and rat: an N-methyl-D-aspartate (NMDA) receptor antagonist. Biol Pharm Bull. 2003 Nov;26(11):1570-3. PubMed PMID: 14600403.

3: Lorber A, Artru AA, Lam MA, Mueller LA, Karpas Z, Roytblat L, Shapira Y. NPS 1506: a novel NMDA receptor antagonist: neuroprotective effects in a model of closed head trauma in rats. J Neurosurg Anesthesiol. 2000 Oct;12(4):345-55. PubMed PMID: 11147383.

4: Leoni MJ, Chen XH, Mueller AL, Cheney J, McIntosh TK, Smith DH. NPS 1506 attenuates cognitive dysfunction and hippocampal neuron death following brain trauma in the rat. Exp Neurol. 2000 Dec;166(2):442-9. PubMed PMID: 11085909.

5: Mueller AL, Artman LD, Balandrin MF, Brady E, Chien Y, DelMar EG, Kierstead A, Marriott TB, Moe ST, Raszkiewicz JL, VanWagenen B, Wells D. NPS 1506, a moderate affinity uncompetitive NMDA receptor antagonist: preclinical summary and clinical experience. Amino Acids. 2000;19(1):177-9. PubMed PMID: 11026487.

6: Mueller AL, Artman LD, Balandrin MF, Brady E, Chien Y, Delmar EG, George K, Kierstead A, Marriott TB, Moe ST, Newman MK, Raszkiewicz JL, Sanguinetti EL, van Wagenen BC, Wells D. NPS 1506, a novel NMDA receptor antagonist and neuroprotectant. Review of preclinical and clinical studies. Ann N Y Acad Sci. 1999;890:450-7. Review. PubMed PMID: 10668449.