L-152,804
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532050

CAS#: 6508-43-6

Description: L-152,804 is a potent, selective non-peptide neuropeptide Y Y5 receptor antagonist (Ki = 26 nM for hY5). L-152,804 displays > 300-fold selectivity over hY1, hY2, and hY4 receptors.


Price and Availability

Size
Price

5mg
USD 240
Size
Price

25mg
USD 590
Size
Price

L-152,804, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532050
Name: L-152,804
CAS#: 6508-43-6
Chemical Formula: C23H26O4
Exact Mass: 366.1831
Molecular Weight: 366.46
Elemental Analysis: C, 75.38; H, 7.15; O, 17.46


Synonym: L-152,804; L 152,804; L152,804.

IUPAC/Chemical Name: 9-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexenyl)-3,3-dimethyl-4,9-dihydro-2H-xanthen-1-one

InChi Key: CCJIUBMPDVWYLU-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H26O4/c1-22(2)9-14(24)20(15(25)10-22)19-13-7-5-6-8-17(13)27-18-12-23(3,4)11-16(26)21(18)19/h5-8,19,24H,9-12H2,1-4H3

SMILES Code: O=C1C(C(C2=C(O)CC(C)(C)CC2=O)C3=C(C=CC=C3)O4)=C4CC(C)(C)C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Long M, Zhou J, Li D, Zheng L, Xu Z, Zhou S. Long-Term Over-Expression of Neuropeptide Y in Hypothalamic Paraventricular Nucleus Contributes to Adipose Tissue Insulin Resistance Partly via the Y5 Receptor. PLoS One. 2015 May 18;10(5):e0126714. doi: 10.1371/journal.pone.0126714. PubMed PMID: 25993471; PubMed Central PMCID: PMC4436377.

2: Sørensen G, Wörtwein G, Fink-Jensen A, Woldbye DP. Neuropeptide Y Y5 receptor antagonism causes faster extinction and attenuates reinstatement in cocaine-induced place preference. Pharmacol Biochem Behav. 2013 Apr;105:151-6. doi: 10.1016/j.pbb.2013.02.010. PubMed PMID: 23454535.

3: Sørensen G, Jensen M, Weikop P, Dencker D, Christiansen SH, Loland CJ, Bengtsen CH, Petersen JH, Fink-Jensen A, Wörtwein G, Woldbye DP. Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice. Psychopharmacology (Berl). 2012 Aug;222(4):565-77. doi: 10.1007/s00213-012-2651-y. PubMed PMID: 22367168.

4: Medeiros PJ, Al-Khazraji BK, Novielli NM, Postovit LM, Chambers AF, Jackson DN. Neuropeptide Y stimulates proliferation and migration in the 4T1 breast cancer cell line. Int J Cancer. 2012 Jul 15;131(2):276-86. doi: 10.1002/ijc.26350. PubMed PMID: 21823118.

5: Schroeder JP, Overstreet DH, Hodge CW. The neuropeptide-Y Y5 receptor antagonist L-152,804 decreases alcohol self-administration in inbred alcohol-preferring (iP) rats. Alcohol. 2005 Jul;36(3):179-86. PubMed PMID: 16377459.

6: Woldbye DP, Nanobashvili A, Sørensen AT, Husum H, Bolwig TG, Sørensen G, Ernfors P, Kokaia M. Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors. Neurobiol Dis. 2005 Dec;20(3):760-72. PubMed PMID: 15979311.

7: Stratford TR, Wirtshafter D. NPY mediates the feeding elicited by muscimol injections into the nucleus accumbens shell. Neuroreport. 2004 Dec 3;15(17):2673-6. PubMed PMID: 15570176.

8: Schroeder JP, Iller KA, Hodge CW. Neuropeptide-Y Y5 receptors modulate the onset and maintenance of operant ethanol self-administration. Alcohol Clin Exp Res. 2003 Dec;27(12):1912-20. PubMed PMID: 14691378.

9: Silva AP, Carvalho AP, Carvalho CM, Malva JO. Functional interaction between neuropeptide Y receptors and modulation of calcium channels in the rat hippocampus. Neuropharmacology. 2003 Feb;44(2):282-92. PubMed PMID: 12623227.

10: Kanatani A, Ishihara A, Iwaasa H, Nakamura K, Okamoto O, Hidaka M, Ito J, Fukuroda T, MacNeil DJ, Van der Ploeg LH, Ishii Y, Okabe T, Fukami T, Ihara M. L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem Biophys Res Commun. 2000 May 27;272(1):169-73. PubMed PMID: 10872822.