ZEN-3694
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MedKoo CAT#: 206793

CAS#: 1643947-30-1 (free base)

Description: ZEN-3694 is an orally bioavailable inhibitor of the bromodomain and extra-terminal (BET) family of proteins, with potential antineoplastic activity. Upon oral administration, the BET inhibitor ZEN-3694 binds to the acetylated lysine recognition motifs in the bromodomains of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histones. This disrupts chromatin remodeling and gene expression.

Chemical Structure

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ZEN-3694
CAS# 1643947-30-1 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 206793
Name: ZEN-3694
CAS#: 1643947-30-1 (free base)
Chemical Formula: C19H19N5O
Exact Mass: 333.16
Molecular Weight: 333.395
Elemental Analysis: C, 68.45; H, 5.74; N, 21.01; O, 4.80

Price and Availability

Size Price Availability Quantity
5mg USD 550 2 Weeks
25mg USD 1450 2 Weeks
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Related CAS #: 1643947-30-1 (free base)   2412912-33-3 (mesylate)   2413439-08-2 (phosphate)    

Synonym: ZEN-3694; ZEN 3694; ZEN3694.

IUPAC/Chemical Name: 6-(3,5-Dimethyl-4-isoxazolyl)-N-methyl-1-(phenylmethyl)-1H-imidazo[4,5-b]pyridin-2-amine

InChi Key: VUFGOHIETLJZRG-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H19N5O/c1-12-17(13(2)25-23-12)15-9-16-18(21-10-15)22-19(20-3)24(16)11-14-7-5-4-6-8-14/h4-10H,11H2,1-3H3,(H,20,21,22)

SMILES Code: CNC1=NC2=C(N1CC3=CC=CC=C3)C=C(C4=C(C)ON=C4C)C=N2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Prevention of the expression of certain growth-promoting genes may lead to an inhibition of proliferation in BET-overexpressing tumor cells. BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during development and cellular growth

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 333.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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