Pruvanserin HCl

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MedKoo CAT#: 529103

CAS#: 443144-27-2 (Pruvanserin HCl)

Description: Pruvanserin HCl a 5-HT2A antagonist potentially for the treatment of insomnia.


Chemical Structure

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Pruvanserin HCl
CAS# 443144-27-2 (Pruvanserin HCl)

Theoretical Analysis

MedKoo Cat#: 529103
Name: Pruvanserin HCl
CAS#: 443144-27-2 (Pruvanserin HCl)
Chemical Formula: C22H22ClFN4O
Exact Mass: 0.00
Molecular Weight: 412.890
Elemental Analysis: C, 64.00; H, 5.37; Cl, 8.59; F, 4.60; N, 13.57; O, 3.87

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 443144-26-1 (Pruvanserin free base)  

Synonym: EMD-281014; LSN-2422347; LY-2420586; LY-2422347; EMD281014; LSN2422347; LY2420586; LY2422347; EMD 281014; LSN 2422347; LY 2420586; LY 2422347

IUPAC/Chemical Name: 7-(4-(4-fluorophenethyl)piperazine-1-carbonyl)-1H-indole-3-carbonitrile hydrochloride

InChi Key: UYGNZRVLPYZLTF-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H21FN4O.ClH/c23-18-6-4-16(5-7-18)8-9-26-10-12-27(13-11-26)22(28)20-3-1-2-19-17(14-24)15-25-21(19)20;/h1-7,15,25H,8-13H2;1H

SMILES Code: FC1=CC=C(CCN2CCN(C(C3=CC=CC4=C3NC=C4C#N)=O)CC2)C=C1.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 412.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Mixcoatl-Zecuatl T, Jolivalt CG. A spinal mechanism of action for duloxetine in a rat model of painful diabetic neuropathy. Br J Pharmacol. 2011 Sep;164(1):159-69. doi: 10.1111/j.1476-5381.2011.01334.x. PubMed PMID: 21410686; PubMed Central PMCID: PMC3171868.

2: Monti JM. Serotonin control of sleep-wake behavior. Sleep Med Rev. 2011 Aug;15(4):269-81. doi: 10.1016/j.smrv.2010.11.003. Review. PubMed PMID: 21459634.

3: Teegarden BR, Al Shamma H, Xiong Y. 5-HT(2A) inverse-agonists for the treatment of insomnia. Curr Top Med Chem. 2008;8(11):969-76. PubMed PMID: 18673166.