KH064 | CAS#393569-31-8 |sPLA2-IIA Inhibitor

KH064
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532001

CAS#: 393569-31-8

Description: KH064 is a orally active inhibitor of sPLA2-IIA.

Chemical Structure

KH064

CAS# 393569-31-8

Instruction

Theoretical Analysis

MedKoo Cat#: 532001
Name: KH064
CAS#: 393569-31-8
Chemical Formula: C31H37NO4
Exact Mass: 487.27
Molecular Weight: 487.640
Elemental Analysis: C, 76.36; H, 7.65; N, 2.87; O, 13.12

Price and Availability

Size	Price	Availability
5mg	USD 520	2 Weeks
10mg	USD 950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: KH064; KH 064; KH-064; 5-BPP acid; sPLA2 Inhibitor

IUPAC/Chemical Name: (4S)-4-(7-phenylheptanoylamino)-5-[4-(phenylmethoxy)phenyl]pentanoic acid

InChi Key: KWLUIYFCMHKLKY-NDEPHWFRSA-N

InChi Code: InChI=1S/C31H37NO4/c33-30(16-10-2-1-5-11-25-12-6-3-7-13-25)32-28(19-22-31(34)35)23-26-17-20-29(21-18-26)36-24-27-14-8-4-9-15-27/h3-4,6-9,12-15,17-18,20-21,28H,1-2,5,10-11,16,19,22-24H2,(H,32,33)(H,34,35)/t28-/m0/s1

SMILES Code: O=C(O)CC[C@H](NC(CCCCCCC1=CC=CC=C1)=O)CC2=CC=C(OCC3=CC=CC=C3)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 487.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kim RR, Malde AK, Nematollahi A, Scott KF, Church WB. Molecular dynamics simulations reveal structural insights into inhibitor binding modes and functionality in human group IIA phospholipase A(2). Proteins. 2017 Jan 5. doi: 10.1002/prot.25235. [Epub ahead of print] PubMed PMID: 28056488.

2: Yang X, Sheng W, Ridgley DM, Haidekker MA, Sun GY, Lee JC. Astrocytes regulate α-secretase-cleaved soluble amyloid precursor protein secretion in neuronal cells: Involvement of group IIA secretory phospholipase A2. Neuroscience. 2015 Aug 6;300:508-17. doi: 10.1016/j.neuroscience.2015.05.052. PubMed PMID: 26037803; PubMed Central PMCID: PMC4485573.

3: Iyer A, Lim J, Poudyal H, Reid RC, Suen JY, Webster J, Prins JB, Whitehead JP, Fairlie DP, Brown L. An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats. Diabetes. 2012 Sep;61(9):2320-9. doi: 10.2337/db11-1179. PubMed PMID: 22923652; PubMed Central PMCID: PMC3425408.

4: Levick S, Loch D, Rolfe B, Reid RC, Fairlie DP, Taylor SM, Brown L. Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A2 in young spontaneously hypertensive rats. J Immunol. 2006 Jun 1;176(11):7000-7. PubMed PMID: 16709861.

5: Gregory LS, Kelly WL, Reid RC, Fairlie DP, Forwood MR. Inhibitors of cyclo-oxygenase-2 and secretory phospholipase A2 preserve bone architecture following ovariectomy in adult rats. Bone. 2006 Jul;39(1):134-42. PubMed PMID: 16473054.

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