UK 357903

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MedKoo CAT#: 529215

CAS#: 247580-98-9

Description: UK 357903 is a phosphodiesterase 5A (PDE5A) inhibitor potentially for the treatment of erectile dysfunction.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-22. Prices are subject to change without notice.

UK 357903 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 529215
Name: UK 357903
CAS#: 247580-98-9
Chemical Formula: C27H34N8O5S
Exact Mass: 582.2373
Molecular Weight: 582.68
Elemental Analysis: C, 55.66; H, 5.88; N, 19.23; O, 13.73; S, 5.50

Synonym: UK-357903, UK357903, UK 357903

IUPAC/Chemical Name: 3-ethyl-5-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-(2-methoxyethoxy)pyridin-3-yl)-2-(pyridin-2-ylmethyl)-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one


InChi Code: InChI=1S/C27H34N8O5S/c1-4-22-23-24(32-35(22)18-19-8-6-7-9-28-19)26(36)31-25(30-23)21-16-20(17-29-27(21)40-15-14-39-3)41(37,38)34-12-10-33(5-2)11-13-34/h6-9,16-17H,4-5,10-15,18H2,1-3H3,(H,30,31,36)


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Gardiner SM, March JE, Kemp PA, Ballard SA, Hawkeswood E, Hughes B, Bennett T. Haemodynamic effects of the selective phosphodiesterase 5 inhibitor, UK-357,903, in conscious SHR. Br J Pharmacol. 2004 Jan;141(1):114-22. PubMed PMID: 14662738; PubMed Central PMCID: PMC1574167.

2: Gardiner SM, March JE, Kemp PA, Ballard SA, Hawkeswood E, Hughes B, Bennett T. Hemodynamic effects of phosphodiesterase 5 and angiotensin-converting enzyme inhibition alone or in combination in conscious SHR. J Pharmacol Exp Ther. 2005 Jan;312(1):265-71. PubMed PMID: 15452190.