WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 528211
CAS#: 581106-09-4
Description: SAD-448 is a cannabinoid receptor type 1 (CB1) agonist potentially for the treatment of ocular hypertension and chronic pain. SAD-448 controls spasticity via action on the peripheral nerve CB1 receptor.
MedKoo Cat#: 528211
Name: SAD-448
CAS#: 581106-09-4
Chemical Formula: C24H28N4O8S
Exact Mass: 532.1628
Molecular Weight: 532.568
Elemental Analysis: C, 54.13; H, 5.30; N, 10.52; O, 24.03; S, 6.02
This product is not in stock, which may be available by custom synthesis.
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Synonym: SAD-448; SAD 448; SAD448
IUPAC/Chemical Name: ethyl 2-((((2-hydroxyethyl)carbamoyl)oxy)methyl)-5,7-dimethyl-3-(2-(N-methylsulfamoyl)phenyl)-4-oxo-3,4-dihydroquinazoline-6-carboxylate
InChi Key: PMBUDILHPXTDNY-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H28N4O8S/c1-5-35-23(31)20-14(2)12-16-21(15(20)3)22(30)28(19(27-16)13-36-24(32)26-10-11-29)17-8-6-7-9-18(17)37(33,34)25-4/h6-9,12,25,29H,5,10-11,13H2,1-4H3,(H,26,32)
SMILES Code: O=C(C1=C(C)C2=C(N=C(COC(NCCO)=O)N(C3=CC=CC=C3S(=O)(NC)=O)C2=O)C=C1C)OCC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 532.568 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Pryce G, Visintin C, Ramagopalan SV, Al-Izki S, De Faveri LE, Nuamah RA, Mein CA, Montpetit A, Hardcastle AJ, Kooij G, de Vries HE, Amor S, Thomas SA, Ledent C, Marsicano G, Lutz B, Thompson AJ, Selwood DL, Giovannoni G, Baker D. Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists. FASEB J. 2014 Jan;28(1):117-30. doi: 10.1096/fj.13-239442. PubMed PMID: 24121462.
