WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 528207
Description: YM-75466 is a factor Xa inhibitor potentially for the treatment of thrombosis. YM-75466 did not prolong coagulation time even at the dose which exerted significant antithrombotic effects, while it decreased TAT level in plasma in a dose-dependent manner. YM-75466 exerted anti-FXa activity but not anti-thrombin activity. YM-75466, unlike heparin, exerts its antithrombotic effect through specific inhibition of FXa without any effect on thrombin.
MedKoo Cat#: 528207
Chemical Formula: C28H35N5O8S2
Molecular Weight: 633.735
Elemental Analysis: C, 53.07; H, 5.57; N, 11.05; O, 20.20; S, 10.12
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Related CAS #: 209187-02-0 (sulfonate); 201933-41-7 (free)
Synonym: YM-75466; YM 75466; YM75466; YM-75466 Free; YM-466; YM 466; YM466; YM-60828; YM 60828; YM60828
IUPAC/Chemical Name: 2-(N-((7-carbamimidoylnaphthalen-2-yl)methyl)-N-(4-((1-(1-iminoethyl)piperidin-4-yl)oxy)phenyl)sulfamoyl)acetic acid compound with methanesulfonic acid (1:1)
InChi Key: YRIFGKTUAWTSFP-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H31N5O5S.CH4O3S/c1-18(28)31-12-10-25(11-13-31)37-24-8-6-23(7-9-24)32(38(35,36)17-26(33)34)16-19-2-3-20-4-5-21(27(29)30)15-22(20)14-19;1-5(2,3)4/h2-9,14-15,25,28H,10-13,16-17H2,1H3,(H3,29,30)(H,33,34);1H3,(H,2,3,4)
SMILES Code: O=C(O)CS(=O)(N(CC1=CC=C2C=CC(C(N)=N)=CC2=C1)C3=CC=C(OC4CCN(C(C)=N)CC4)C=C3)=O.CS(=O)(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 633.735 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Sato K, Kaku S, Hirayama F, Koshio H, Matsumoto Y, Kawasaki T, Iizumi Y. Antithrombotic effect of YM-75466 is separated from its effect on bleeding time and coagulation time. Eur J Pharmacol. 1998 Jul 3;352(1):59-63. PubMed PMID: 9718268.
2: Sato K, Taniuchi Y, Kawasaki T, Hirayama F, Koshio H, Matsumoto Y, Iizumi Y. Comparison of the anticoagulant and antithrombotic effects of YM-75466, a novel orally-active factor Xa inhibitor, and warfarin in mice. Jpn J Pharmacol. 1998 Oct;78(2):191-7. PubMed PMID: 9829622.
3: Sato K, Taniuchi Y, Kawasaki T, Hirayama F, Koshio H, Matsumoto Y. Relationship between the antithrombotic effect of YM-75466, a novel factor Xa inhibitor, and coagulation parameters in rats. Eur J Pharmacol. 1998 Apr 24;347(2-3):231-6. PubMed PMID: 9653887.