YM-75466

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 528207

CAS#: 209187-02-0

Description: YM-75466 is a factor Xa inhibitor potentially for the treatment of thrombosis. YM-75466 did not prolong coagulation time even at the dose which exerted significant antithrombotic effects, while it decreased TAT level in plasma in a dose-dependent manner. YM-75466 exerted anti-FXa activity but not anti-thrombin activity. YM-75466, unlike heparin, exerts its antithrombotic effect through specific inhibition of FXa without any effect on thrombin.


Chemical Structure

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YM-75466
CAS# 209187-02-0

Theoretical Analysis

MedKoo Cat#: 528207
Name: YM-75466
CAS#: 209187-02-0
Chemical Formula: C28H35N5O8S2
Exact Mass:
Molecular Weight: 633.735
Elemental Analysis: C, 53.07; H, 5.57; N, 11.05; O, 20.20; S, 10.12

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 209187-02-0 (sulfonate); 201933-41-7 (free)  

Synonym: YM-75466; YM 75466; YM75466; YM-75466 Free; YM-466; YM 466; YM466; YM-60828; YM 60828; YM60828

IUPAC/Chemical Name: 2-(N-((7-carbamimidoylnaphthalen-2-yl)methyl)-N-(4-((1-(1-iminoethyl)piperidin-4-yl)oxy)phenyl)sulfamoyl)acetic acid compound with methanesulfonic acid (1:1)

InChi Key: YRIFGKTUAWTSFP-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H31N5O5S.CH4O3S/c1-18(28)31-12-10-25(11-13-31)37-24-8-6-23(7-9-24)32(38(35,36)17-26(33)34)16-19-2-3-20-4-5-21(27(29)30)15-22(20)14-19;1-5(2,3)4/h2-9,14-15,25,28H,10-13,16-17H2,1H3,(H3,29,30)(H,33,34);1H3,(H,2,3,4)

SMILES Code: O=C(O)CS(=O)(N(CC1=CC=C2C=CC(C(N)=N)=CC2=C1)C3=CC=C(OC4CCN(C(C)=N)CC4)C=C3)=O.CS(=O)(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 633.735 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Sato K, Kaku S, Hirayama F, Koshio H, Matsumoto Y, Kawasaki T, Iizumi Y. Antithrombotic effect of YM-75466 is separated from its effect on bleeding time and coagulation time. Eur J Pharmacol. 1998 Jul 3;352(1):59-63. PubMed PMID: 9718268.

2: Sato K, Taniuchi Y, Kawasaki T, Hirayama F, Koshio H, Matsumoto Y, Iizumi Y. Comparison of the anticoagulant and antithrombotic effects of YM-75466, a novel orally-active factor Xa inhibitor, and warfarin in mice. Jpn J Pharmacol. 1998 Oct;78(2):191-7. PubMed PMID: 9829622.

3: Sato K, Taniuchi Y, Kawasaki T, Hirayama F, Koshio H, Matsumoto Y. Relationship between the antithrombotic effect of YM-75466, a novel factor Xa inhibitor, and coagulation parameters in rats. Eur J Pharmacol. 1998 Apr 24;347(2-3):231-6. PubMed PMID: 9653887.