OSI-296

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558252

CAS#: 1175296-94-2

Description: OSI-296 is a potent and dual inhibitor of cMET and RON kinases with IC50 for cMet = 42 nM and IC50 for sfRon = 200 nM. OSI-206 shows in vivo efficacy in tumor xenografts models upon oral dosing and is well tolerated. OSI-296 also reduced tumour growth in the bone.

Chemical Structure

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OSI-296
CAS# 1175296-94-2
Instruction

Theoretical Analysis

MedKoo Cat#: 558252
Name: OSI-296
CAS#: 1175296-94-2
Chemical Formula: C21H19Cl2FN4O3
Exact Mass: 464.081
Molecular Weight: 465.3064
Elemental Analysis: C, 54.21; H, 4.12; Cl, 15.24; F, 4.08; N, 12.04; O, 10.32

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: OSI-296; OSI 296; OSI296.

IUPAC/Chemical Name: 4-[6-Amino-7-[[(R)-1-(2,6-dichloro-3-fluorophenyl)ethyl]oxy]furo[3,2-c]pyridin-3-yl]-3,6-dihydro-2H-pyridine-1-carboxamide

InChi Key: LVYXERPKYAQGKM-SNVBAGLBSA-N

InChi Code: InChI=1S/C21H19Cl2FN4O3/c1-10(16-14(22)2-3-15(24)17(16)23)31-19-18-12(8-27-20(19)25)13(9-30-18)11-4-6-28(7-5-11)21(26)29/h2-4,8-10H,5-7H2,1H3,(H2,25,27)(H2,26,29)/t10-/m1/s1

SMILES Code: O=C(N1CC=C(C2=COC3=C2C=NC(N)=C3O[C@@H](C4=C(Cl)C=CC(F)=C4Cl)C)CC1)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 465.3064 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Steinig AG, Li AH, Wang J, Chen X, Dong H, Ferraro C, Jin M, Kadalbajoo M,
Kleinberg A, Stolz KM, Tavares-Greco PA, Wang T, Albertella MR, Peng Y, Crew L,
Kahler J, Kan J, Schulz R, Cooke A, Bittner M, Turton RW, Franklin M, Gokhale P,
Landfair D, Mantis C, Workman J, Wild R, Pachter J, Epstein D, Mulvihill MJ.
Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of
cMET and RON kinases. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4381-7. doi:
10.1016/j.bmcl.2013.05.074. PubMed PMID: 23773865.

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OSI-296