JNJ1930942

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531983

CAS#: 929562-28-7

Description: JNJ1930942 is a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor.


Price and Availability

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JNJ1930942 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 531983
Name: JNJ1930942
CAS#: 929562-28-7
Chemical Formula: C16H11F4N3OS
Exact Mass: 369.0559
Molecular Weight: 369.34
Elemental Analysis: C, 52.03; H, 3.00; F, 20.58; N, 11.38; O, 4.33; S, 8.68


Synonym: JNJ1930942; JNJ 1930942; JNJ-1930942.

IUPAC/Chemical Name: (2-{[4-fluoro-3-(trifluoromethyl)phenyl]amino}-4-(pyridin-4-yl)-1,3-thiazol-5-yl)methanol

InChi Key: JBSVHWCIKVSTTH-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H11F4N3OS/c17-12-2-1-10(7-11(12)16(18,19)20)22-15-23-14(13(8-24)25-15)9-3-5-21-6-4-9/h1-7,24H,8H2,(H,22,23)

SMILES Code: OCC1=C(C2=CC=NC=C2)N=C(NC3=CC=C(F)C(C(F)(F)F)=C3)S1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Dinklo T, Shaban H, Thuring JW, Lavreysen H, Stevens KE, Zheng L, Mackie C, Grantham C, Vandenberk I, Meulders G, Peeters L, Verachtert H, De Prins E, Lesage AS. Characterization of 2-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanol (JNJ-1930942), a novel positive allosteric modulator of the {alpha}7 nicotinic acetylcholine receptor. J Pharmacol Exp Ther. 2011 Feb;336(2):560-74. doi: 10.1124/jpet.110.173245. PubMed PMID: 21084390.