WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 529204
Description: Px-104, also known as Px-102, is a farnesoid X receptor (FXR) agonist potentially for the treatment of non-alcoholic fatty liver disease.
MedKoo Cat#: 529204
Chemical Formula: C29H22Cl3NO4
Exact Mass: 553.0614
Molecular Weight: 554.84
Elemental Analysis: C, 62.78; H, 4.00; Cl, 19.17; N, 2.52; O, 11.53
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Related CAS #: 1268244-85-4
Synonym: Px-104; Px104; Px 104; Px-102; Px102; Px 102
IUPAC/Chemical Name: 4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)benzoic acid
InChi Key: XBUXXJUEBFDQHD-UHFFFAOYSA-N
InChi Code: InChI=1S/C29H22Cl3NO4/c30-23-2-1-3-24(31)26(23)27-22(28(37-33-27)16-6-7-16)14-36-18-10-11-19(25(32)12-18)21-13-20(21)15-4-8-17(9-5-15)29(34)35/h1-5,8-12,16,20-21H,6-7,13-14H2,(H,34,35)
SMILES Code: O=C(O)C1=CC=C(C2C(C3=CC=C(OCC4=C(C5CC5)ON=C4C6=C(Cl)C=CC=C6Cl)C=C3Cl)C2)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 554.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Gege C, Kinzel O, Steeneck C, Schulz A, Kremoser C. Knocking on FXR's door:
the "hammerhead"-structure series of FXR agonists - amphiphilic isoxazoles with
potent in vitro and in vivo activities. Curr Top Med Chem. 2014;14(19):2143-58.
Review. PubMed PMID: 25388536.