ICI 192605
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531966

CAS#: 117621-64-4

Description: ICI 192605 is a potent thromboxane A2 receptor (TP receptor) antagonist.


Chemical Structure

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ICI 192605
CAS# 117621-64-4

Theoretical Analysis

MedKoo Cat#: 531966
Name: ICI 192605
CAS#: 117621-64-4
Chemical Formula: C22H23ClO5
Exact Mass: 402.1234
Molecular Weight: 402.87
Elemental Analysis: C, 65.59; H, 5.75; Cl, 8.80; O, 19.86

Price and Availability

Size Price Availability Quantity
5.0mg USD 230.0 2 Weeks
25.0g USD 580.0 2 Weeks
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Synonym: ICI 192605 ; ICI192605; ICI-192605 .

IUPAC/Chemical Name: (E)-6-[(2S,4S,5R)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]hex-4-enoic acid

InChi Key: WHUIENZXNGAHQI-BNGKFCBFSA-N

InChi Code: InChI=1S/C22H23ClO5/c23-18-11-6-4-9-16(18)22-27-14-15(8-2-1-3-13-20(25)26)21(28-22)17-10-5-7-12-19(17)24/h1-2,4-7,9-12,15,21-22,24H,3,8,13-14H2,(H,25,26)/b2-1+/t15-,21+,22+/m1/s1

SMILES Code: O=C(O)CC/C=C/C[C@H]1[C@@H](C2=CC=CC=C2O)O[C@@H](C3=CC=CC=C3Cl)OC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 402.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Brown GR, Foubister AJ, Hudson JA. Improved synthetic routes to the novel thromboxane receptor antagonist ICI 192605: activity of synthetic 1,3-dioxane intermediates. J Pharm Pharmacol. 1990 Jan;42(1):53-5. PubMed PMID: 1969951.

2: Brewster AG, Brown GR, Foubister AJ, Jessup R, Smithers MJ. The synthesis of a novel thromboxane receptor antagonist 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl) hexenoic acid ICI 192605. Prostaglandins. 1988 Aug;36(2):173-8. PubMed PMID: 2973084.