WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531964

CAS#: 325457-89-4

Description: ICA-27243 is a novel, potent and selective activator of M-current and KCNQ2/Q3 channels. ICA-27243 enhances KCNQ channel activation by shifting channel opening to more hyperpolarized potentials.

Price and Availability




ICA-27243 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 531964
Name: ICA-27243
CAS#: 325457-89-4
Chemical Formula: C12H7ClF2N2O
Exact Mass: 268.0215
Molecular Weight: 268.65
Elemental Analysis: C, 53.65; H, 2.63; Cl, 13.20; F, 14.14; N, 10.43; O, 5.96

Synonym: ICA-27243; ICA 27243; ICA27243.

IUPAC/Chemical Name: N-(6-chloropyridin-3-yl)-3,4-difluorobenzamide


InChi Code: InChI=1S/C12H7ClF2N2O/c13-11-4-2-8(6-16-11)17-12(18)7-1-3-9(14)10(15)5-7/h1-6H,(H,17,18)

SMILES Code: O=C(NC1=CC=C(Cl)N=C1)C2=CC=C(F)C(F)=C2

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Sander SE, Lambrecht C, Richter A. The K(V)7.2/3 preferring channel opener ICA 27243 attenuates L-DOPA-induced dyskinesia in hemiparkinsonian rats. Neurosci Lett. 2013 Jun 17;545:59-63. doi: 10.1016/j.neulet.2013.04.017. PubMed PMID: 23623937.

2: Blom SM, Schmitt N, Jensen HS. Differential effects of ICA-27243 on cloned K(V)7 channels. Pharmacology. 2010;86(3):174-81. doi: 10.1159/000317525. PubMed PMID: 20714208.

3: Padilla K, Wickenden AD, Gerlach AC, McCormack K. The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site. Neurosci Lett. 2009 Nov 13;465(2):138-42. doi: 10.1016/j.neulet.2009.08.071. PubMed PMID: 19733209.

4: Roeloffs R, Wickenden AD, Crean C, Werness S, McNaughton-Smith G, Stables J, McNamara JO, Ghodadra N, Rigdon GC. In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models. J Pharmacol Exp Ther. 2008 Sep;326(3):818-28. doi: 10.1124/jpet.108.137794. PubMed PMID: 18577704.

5: Wickenden AD, Krajewski JL, London B, Wagoner PK, Wilson WA, Clark S, Roeloffs R, McNaughton-Smith G, Rigdon GC. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol. 2008 Mar;73(3):977-86. PubMed PMID: 18089837.