GW0072

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531888

CAS#: 321557-86-2

Description: GW0072 is a PPARγ partial agonist.

Chemical Structure

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GW0072
CAS# 321557-86-2
Instruction

Theoretical Analysis

MedKoo Cat#: 531888
Name: GW0072
CAS#: 321557-86-2
Chemical Formula: C37H46N2O4S
Exact Mass: 614.32
Molecular Weight: 614.850
Elemental Analysis: C, 72.28; H, 7.54; N, 4.56; O, 10.41; S, 5.21

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: GW0072; GW 0072; GW-0072.

IUPAC/Chemical Name: 4-[4-[(2S,5S)-5-[2-(bis(phenylmethyl)amino)-2-oxoethyl]-2-heptyl-4-oxo-1,3-thiazolidin-3-yl]butyl]benzoic acid

InChi Key: GHJJBEKMPCOSRH-LRHLLKFHSA-N

InChi Code: InChI=1S/C37H46N2O4S/c1-2-3-4-5-12-20-35-39(25-14-13-15-29-21-23-32(24-22-29)37(42)43)36(41)33(44-35)26-34(40)38(27-30-16-8-6-9-17-30)28-31-18-10-7-11-19-31/h6-11,16-19,21-24,33,35H,2-5,12-15,20,25-28H2,1H3,(H,42,43)/t33-,35-/m0/s1

SMILES Code: O=C(O)C1=CC=C(CCCCN2[C@H](CCCCCCC)S[C@@H](CC(N(CC3=CC=CC=C3)CC4=CC=CC=C4)=O)C2=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 614.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Aci-Sèche S, Genest M, Garnier N. Ligand entry pathways in the ligand binding domain of PPARγ receptor. FEBS Lett. 2011 Aug 19;585(16):2599-603. doi: 10.1016/j.febslet.2011.07.014. PubMed PMID: 21782815.

2: Shan W, Palkar PS, Murray IA, McDevitt EI, Kennett MJ, Kang BH, Isom HC, Perdew GH, Gonzalez FJ, Peters JM. Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression. Toxicol Sci. 2008 Oct;105(2):418-28. doi: 10.1093/toxsci/kfn142. PubMed PMID: 18622026; PubMed Central PMCID: PMC2527639.

3: Genest D, Garnier N, Arrault A, Marot C, Morin-Allory L, Genest M. Ligand-escape pathways from the ligand-binding domain of PPARgamma receptor as probed by molecular dynamics simulations. Eur Biophys J. 2008 Apr;37(4):369-79. PubMed PMID: 17929009.

4: Sheu SH, Kaya T, Waxman DJ, Vajda S. Exploring the binding site structure of the PPAR gamma ligand-binding domain by computational solvent mapping. Biochemistry. 2005 Feb 1;44(4):1193-209. PubMed PMID: 15667213.

5: Rival Y, Stennevin A, Puech L, Rouquette A, Cathala C, Lestienne F, Dupont-Passelaigue E, Patoiseau JF, Wurch T, Junquéro D. Human adipocyte fatty acid-binding protein (aP2) gene promoter-driven reporter assay discriminates nonlipogenic peroxisome proliferator-activated receptor gamma ligands. J Pharmacol Exp Ther. 2004 Nov;311(2):467-75. PubMed PMID: 15273253.