WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530516

CAS#: Unknown

Description: YKL-04-085 is a potent inhibitor of viral translation and exhibits cellular antiviral activity at 35-fold lower concentrations relative to inhibition of host-cell proliferation. YKL-04-085 demonstrated good inhibition of translation of the DENV2(GVD) reporter replicon in cellulo.

Chemical Structure

CAS# Unknown

Theoretical Analysis

MedKoo Cat#: 530516
Name: YKL-04-085
CAS#: Unknown
Chemical Formula: C30H29N5O2
Exact Mass: 491.2321
Molecular Weight: 491.595
Elemental Analysis: C, 73.30; H, 5.95; N, 14.25; O, 6.51

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Synonym: YKL-04-085; YKL04-085; YKL 04-085; YKL-04085; YKL04085; YKL 04085.

IUPAC/Chemical Name: (E)-4-(dimethylamino)-N-(2-methyl-5-(9-(1-methyl-1H-pyrazol-4-yl)-2-oxobenzo[h]quinolin-1(2H)-yl)phenyl)but-2-enamide


InChi Code: InChI=1S/C30H29N5O2/c1-20-7-13-25(17-27(20)32-28(36)6-5-15-33(2)3)35-29(37)14-12-22-10-8-21-9-11-23(16-26(21)30(22)35)24-18-31-34(4)19-24/h5-14,16-19H,15H2,1-4H3,(H,32,36)/b6-5+

SMILES Code: O=C1N(C2=CC(NC(/C=C/CN(C)C)=O)=C(C=C2)C)C3=C(C=CC4=CC=C(C5=CN(C)N=C5)C=C43)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 491.595 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Structure–Activity Relationship Study of QL47: A Broad-Spectrum Antiviral Agent Yanke LiangMelissanne de WispelaereMargot CarocciQingsong LiuJinhua WangPriscilla L. YangNathanael S. Gray Publication Date (Web): February 3, 2017 (Letter) DOI: 10.1021/acsmedchemlett.7b00008