WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 529432
Description: XC-302, also called Puquitinib, is a multi-targeted inhibitor that induces autophagy via inhibiting the PI3K/AKT/mTOR signaling pathway in nasopharyngeal cancer cells.
MedKoo Cat#: 529432
Name: XC-302 free base
Chemical Formula: C17H15N7
Exact Mass: 317.1389
Molecular Weight: 317.35
Elemental Analysis: C, 64.34; H, 4.76; N, 30.90
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: XC-302; XC302; XC 302; Puquitinib
IUPAC/Chemical Name: N6-cyclopropyl-N2-(quinolin-6-yl)-9H-purine-2,6-diamine
InChi Key: QUTFBURLXCODBH-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H15N7/c1-2-10-8-12(5-6-13(10)18-7-1)22-17-23-15-14(19-9-20-15)16(24-17)21-11-3-4-11/h1-2,5-9,11H,3-4H2,(H3,19,20,21,22,23,24)
SMILES Code: C1(NC2=NC(NC3CC3)=C(N=CN4)C4=N2)=CC=C5C(C=CC=N5)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 317.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Wang KF, Yang H, Jiang WQ, Li S, Cai YC. Puquitinib mesylate (XC-302) induces autophagy via inhibiting the PI3K/AKT/mTOR signaling pathway in nasopharyngeal cancer cells. Int J Mol Med. 2015 Dec;36(6):1556-62. doi: 10.3892/ijmm.2015.2378. PubMed PMID: 26499488; PubMed Central PMCID: PMC4678157.
2: Yang H, Wang Y, Zhan J, Xia Y, Sun P, Bi XW, Liu PP, Li ZM, Li S, Zou BY, Jiang WQ. Puquitinib mesylate, an inhibitor of phosphatidylinositol 3-kinase p110δ, for treating relapsed or refractory non-Hodgkin's lymphoma. Oncotarget. 2015 Dec 22;6(41):44049-56. doi: 10.18632/oncotarget.5833. PubMed PMID: 26510909; PubMed Central PMCID: PMC4791286.