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MedKoo CAT#: 530514

CAS#: Unknown

Description: NEU-1923 is a potent inhibitor of T. brucei proliferation with improved drug-like properties (EC50= 0.37 μM). Human African trypanosomiasis (HAT), Chagas disease, and leishmaniasis present a significant burden across the developing world. Existing therapeutics for these protozoal neglected tropical diseases suffer from severe side effects and toxicity.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-22. Prices are subject to change without notice.

NEU-1923 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 530514
Name: NEU-1923
CAS#: Unknown
Chemical Formula: C23H20ClN5O3S
Exact Mass: 481.0975
Molecular Weight: 481.955
Elemental Analysis: C, 57.32; H, 4.18; Cl, 7.36; N, 14.53; O, 9.96; S, 6.65

Synonym: NEU-1923; NEU-1923; NEU-1923.

IUPAC/Chemical Name: N-(5-chloropyrimidin-2-yl)-6-(4-(morpholinosulfonyl)phenyl)quinolin-4-amine


InChi Code: InChI=1S/C23H20ClN5O3S/c24-18-14-26-23(27-15-18)28-22-7-8-25-21-6-3-17(13-20(21)22)16-1-4-19(5-2-16)33(30,31)29-9-11-32-12-10-29/h1-8,13-15H,9-12H2,(H,25,26,27,28)

SMILES Code: O=S(C1=CC=C(C2=CC=C3N=CC=C(NC4=NC=C(Cl)C=N4)C3=C2)C=C1)(N5CCOCC5)=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Additional Information

Taken together, human African trypanosomiasis (HAT), Chagas disease, and leishmaniasis are responsible for 4.4 million disability adjusted life years (DALY) and 70,000 deaths annually.1 Caused by the protozoan parasites Trypanosoma brucei, T. cruzi, and Leishmania spp., respectively, these diseases are spread through insect vectors across Latin America, Africa, and parts of southern Asia.


Antiparasitic Lead Discovery: Toward Optimization of a Chemotype with Activity Against Multiple Protozoan Parasites
William DevineSarah M. ThomasJessey ErathKelly A. BachovchinPatricia J. LeeSusan E. LeedAna RodriguezRichard J. SciottiKojo Mensa-Wilmotand Michael P. Pollastri
Publication Date (Web): February 5, 2017 (Letter)
DOI: 10.1021/acsmedchemlett.7b00011