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MedKoo CAT#: 527709

CAS#: 21914-07-8

Description: T-2007, also known as DPB and 5,5-Diphenylbarbituric acid, is an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist and gamma-aminobutyric acid (GABA) receptor agonist potentially for the treatment of epilepsy. T2007 and its analogs upregulates CYP3A4 and MDR1. T-2007 depressed both the degree and the duration of posttetanic potentiation (PTP) in a dose-dependent manner.

Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-07-02. Prices are subject to change without notice.

T-2007 (DPB) is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 527709
Name: T-2007
CAS#: 21914-07-8
Chemical Formula: C16H12N2O3
Exact Mass: 280.0848
Molecular Weight: 280.283
Elemental Analysis: C, 68.56; H, 4.32; N, 9.99; O, 17.12

Synonym: T-2007, T-2007, T-2007, DPB, 5,5-Diphenylbarbituric acid

IUPAC/Chemical Name: 5,5-diphenylpyrimidine-2,4,6(1H,3H,5H)-trione


InChi Code: InChI=1S/C16H12N2O3/c19-13-16(11-7-3-1-4-8-11,12-9-5-2-6-10-12)14(20)18-15(21)17-13/h1-10H,(H2,17,18,19,20,21)


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Fan J, Maeng HJ, Du Y, Kwan D, Pang KS. Transport of 5,5-diphenylbarbituric acid and its precursors and their effect on P-gp, MRP2 and CYP3A4 in Caco-2 and LS180 cells. Eur J Pharm Sci. 2011 Jan 18;42(1-2):19-29. doi: 10.1016/j.ejps.2010.10.001. PubMed PMID: 20955791.

2: Thacker DL, Abernethy DR, Raines A, Flockhart DA. Method for the determination of 5,5-diphenylbarbituric acid and its separation from 1,3-dimethoxymethyl-5,5-diphenylbarbituric acid in plasma by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1998 Jun 12;710(1-2):149-55. PubMed PMID: 9686882.

3: Nims RW, McClain RM, Manchand PS, Belica PS, Thomas PE, Mellini DW, Utermahlen WE Jr, Lubet RA. Comparative pharmacodynamics of hepatic cytochrome P450 2B induction by 5,5-diphenyl- and 5,5-diethyl-substituted barbiturates and hydantoins in the male F344/NCr rat. J Pharmacol Exp Ther. 1994 Jul;270(1):348-55. PubMed PMID: 8035330.

4: Zavadil AP 3rd, Dretchen KL, Raines A. Diphenylbarbituric acid: its effects on neuromuscular and spinal cord function in the cat. Epilepsia. 1985 Mar-Apr;26(2):158-66. PubMed PMID: 2985376.

5: Huguenard JR, Wilson WA. Suppression of repetitive firing of neurons by diphenylbarbituric acid. J Pharmacol Exp Ther. 1985 Jan;232(1):228-31. PubMed PMID: 3965694.

6: Iadarola MJ, Fanelli RJ, McNamara JO, Wilson WA. Comparison of the effects of diphenylbarbituric acid, phenobarbital, pentobarbital and secobarbital on GABA-mediated inhibition and benzodiazepine binding. J Pharmacol Exp Ther. 1985 Jan;232(1):127-33. PubMed PMID: 2981311.