T-2007

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527709

CAS#: 21914-07-8

Description: T-2007, also known as DPB and 5,5-Diphenylbarbituric acid, is an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist and gamma-aminobutyric acid (GABA) receptor agonist potentially for the treatment of epilepsy. T2007 and its analogs upregulates CYP3A4 and MDR1. T-2007 depressed both the degree and the duration of posttetanic potentiation (PTP) in a dose-dependent manner.


Chemical Structure

img
T-2007
CAS# 21914-07-8

Theoretical Analysis

MedKoo Cat#: 527709
Name: T-2007
CAS#: 21914-07-8
Chemical Formula: C16H12N2O3
Exact Mass: 280.0848
Molecular Weight: 280.283
Elemental Analysis: C, 68.56; H, 4.32; N, 9.99; O, 17.12

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: T-2007, T-2007, T-2007, DPB, 5,5-Diphenylbarbituric acid

IUPAC/Chemical Name: 5,5-diphenylpyrimidine-2,4,6(1H,3H,5H)-trione

InChi Key: IKVPZYAOGOJTLK-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H12N2O3/c19-13-16(11-7-3-1-4-8-11,12-9-5-2-6-10-12)14(20)18-15(21)17-13/h1-10H,(H2,17,18,19,20,21)

SMILES Code: O=C(NC(C1(C2=CC=CC=C2)C3=CC=CC=C3)=O)NC1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 280.283 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Fan J, Maeng HJ, Du Y, Kwan D, Pang KS. Transport of 5,5-diphenylbarbituric acid and its precursors and their effect on P-gp, MRP2 and CYP3A4 in Caco-2 and LS180 cells. Eur J Pharm Sci. 2011 Jan 18;42(1-2):19-29. doi: 10.1016/j.ejps.2010.10.001. PubMed PMID: 20955791.

2: Thacker DL, Abernethy DR, Raines A, Flockhart DA. Method for the determination of 5,5-diphenylbarbituric acid and its separation from 1,3-dimethoxymethyl-5,5-diphenylbarbituric acid in plasma by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1998 Jun 12;710(1-2):149-55. PubMed PMID: 9686882.

3: Nims RW, McClain RM, Manchand PS, Belica PS, Thomas PE, Mellini DW, Utermahlen WE Jr, Lubet RA. Comparative pharmacodynamics of hepatic cytochrome P450 2B induction by 5,5-diphenyl- and 5,5-diethyl-substituted barbiturates and hydantoins in the male F344/NCr rat. J Pharmacol Exp Ther. 1994 Jul;270(1):348-55. PubMed PMID: 8035330.

4: Zavadil AP 3rd, Dretchen KL, Raines A. Diphenylbarbituric acid: its effects on neuromuscular and spinal cord function in the cat. Epilepsia. 1985 Mar-Apr;26(2):158-66. PubMed PMID: 2985376.

5: Huguenard JR, Wilson WA. Suppression of repetitive firing of neurons by diphenylbarbituric acid. J Pharmacol Exp Ther. 1985 Jan;232(1):228-31. PubMed PMID: 3965694.

6: Iadarola MJ, Fanelli RJ, McNamara JO, Wilson WA. Comparison of the effects of diphenylbarbituric acid, phenobarbital, pentobarbital and secobarbital on GABA-mediated inhibition and benzodiazepine binding. J Pharmacol Exp Ther. 1985 Jan;232(1):127-33. PubMed PMID: 2981311.