FR167344

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531787

CAS#: 215258-13-2

Description: FR167344 is a novel, potent and orally active nonpeptide bradykinin B2 receptor antagonist used in vivo models of inflammation.

Chemical Structure

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FR167344
CAS# 215258-13-2
Instruction

Theoretical Analysis

MedKoo Cat#: 531787
Name: FR167344
CAS#: 215258-13-2
Chemical Formula: C30H28BrCl2N5O4
Exact Mass: 671.07
Molecular Weight: 673.390
Elemental Analysis: C, 53.51; H, 4.19; Br, 11.87; Cl, 10.53; N, 10.40; O, 9.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: FR167344; FR-167344; FR 167344.

IUPAC/Chemical Name: 4-[(E)-3-[[2-[[3-[(3-bromo-2-methylimidazo[1,2-a]pyridin-8-yl)oxymethyl]-2,4-dichlorophenyl]-methylamino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N,N-dimethylbenzamide

InChi Key: NDOBHDUXUJNXHX-NTEUORMPSA-N

InChi Code: InChI=1S/C30H28BrCl2N5O4/c1-18-28(31)38-15-5-6-24(29(38)35-18)42-17-21-22(32)12-13-23(27(21)33)37(4)26(40)16-34-25(39)14-9-19-7-10-20(11-8-19)30(41)36(2)3/h5-15H,16-17H2,1-4H3,(H,34,39)/b14-9+

SMILES Code: O=C(N(C)C)C1=CC=C(/C=C/C(NCC(N(C2=CC=C(Cl)C(COC3=CC=CN4C3=NC(C)=C4Br)=C2Cl)C)=O)=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 673.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Asano M, Sawai H, Hatori C, Inamura N, Fujiwara T, Nakahara K. Effects of a nonpeptide bradykinin B2 receptor antagonist, FR167344, on guinea-pig tracheal smooth muscle bradykinin receptors. Can J Physiol Pharmacol. 1998 Oct-Nov;76(10-11):1051-5. PubMed PMID: 10100888.

2: Asano M, Hatori C, Inamura N, Sawai H, Hirosumi J, Fujiwara T, Nakahara K. Effects of a nonpeptide bradykinin B2 receptor antagonist, FR167344, on different in vivo animal models of inflammation. Br J Pharmacol. 1997 Dec;122(7):1436-40. PubMed PMID: 9421292; PubMed Central PMCID: PMC1565090.

3: Inamura N, Asano M, Hatori C, Sawai H, Hirosumi J, Fujiwara T, Kayakiri H, Satoh S, Abe Y, Inoue T, Sawada Y, Oku T, Nakahara K. Pharmacological characterization of a novel, orally active, nonpeptide bradykinin B2 receptor antagonist, FR167344. Eur J Pharmacol. 1997 Aug 20;333(1):79-86. PubMed PMID: 9311664.

4: Aramori I, Zenkoh J, Morikawa N, O'Donnell N, Asano M, Nakamura K, Iwami M, Kojo H, Notsu Y. Novel subtype-selective nonpeptide bradykinin receptor antagonists FR167344 and FR173657. Mol Pharmacol. 1997 Feb;51(2):171-6. PubMed PMID: 9203620.