Valibose

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558288

CAS#: 83470-79-5

Description: Valibose An α-glucosidase inhibitor potentially for the treatment of diabetes. Valibose significantly decreased postprandial and fasting blood glucose, urine glucose, and reduced the levels of serum fructosamine. Valibose also decreased plasma triglyceride and cholesterol levels. Valibose ameliorated metabolic disturbance of glucose and lipids. In addition, valibose markedly reduced level of serum NAG and BUN, and decreased the weight index of kidney.

Chemical Structure

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Valibose
CAS# 83470-79-5
Instruction

Theoretical Analysis

MedKoo Cat#: 558288
Name: Valibose
CAS#: 83470-79-5
Chemical Formula: C10H21NO6
Exact Mass: 251.14
Molecular Weight: 251.279
Elemental Analysis: C, 47.80; H, 8.42; N, 5.57; O, 38.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Valibose

IUPAC/Chemical Name: (1R,2S,3S,4S,6R)-4-((1,3-dihydroxypropan-2-yl)amino)-6-(hydroxymethyl)cyclohexane-1,2,3-triol

InChi Key: LWJUMCBIHCZWBT-JTBFQXKRSA-N

InChi Code: InChI=1S/C10H21NO6/c12-2-5-1-7(11-6(3-13)4-14)9(16)10(17)8(5)15/h5-17H,1-4H2/t5-,7+,8-,9+,10+/m1/s1

SMILES Code: O[C@H]1[C@@H](NC(CO)CO)C[C@H](CO)[C@@H](O)[C@@H]1O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 251.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Liu Q, Liu SN, Sun SJ, Shen ZF. [Valibose, an alpha-glucosidase inhibitor, ameliorates the metabolic disorder of glucose and lipids and the nephropathy in streptozotocin-induced diabetic rats]. Yao Xue Xue Bao. 2013 Aug;48(8):1227-32. Chinese. PubMed PMID: 24187828.

2: Zhong S, Zhong D, Chen X. Improved and simplified liquid chromatography/electrospray ionization mass spectrometry method for the analysis of underivatized glucosamine in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jul 1;854(1-2):291-8. PubMed PMID: 17544344.

3: Dai XM, An N, Wu JM, Li HY, Zhang QM. Development and validation of HPLC-UV-MS method for the control of four anti-diabetic drugs in suspected counterfeit products. Yao Xue Xue Bao. 2010 Mar;45(3):347-52. PubMed PMID: 21348424.