E4031 HCl
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MedKoo CAT#: 531769

CAS#: 113559-13-0 (2HCl)

Description: E4031 selectively blocks hERG K+ channels. E4031 inhibits the rapid delayed-rectifier K+ current (IKr) and reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na+ or Ca2+ inward currents. E4031 is a class III antiarrhythmic agent.


Price and Availability

Size Price Shipping out time Quantity
50mg USD 250 2 weeks
100mg USD 450 2 weeks
200mg USD 750 2 weeks
500mg USD 1650 2 weeks
1g USD 2750 2 weeks
2g USD 3950 2 weeks
5g USD 6950 2 weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-31. Prices are subject to change without notice.

E4031 HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 531769
Name: E4031 HCl
CAS#: 113559-13-0 (2HCl)
Chemical Formula: C21H29Cl2N3O3S
Exact Mass: 401.1773
Molecular Weight: 474.44
Elemental Analysis: C, 53.16; H, 6.16; Cl, 14.94; N, 8.86; O, 10.12; S, 6.76


Related CAS #: 113558-89-7 (free base)   113559-13-0 (2HCl)  

Synonym: E4031; E-4031; E 4031; E4031 HCl; E4031 hydrochloride

IUPAC/Chemical Name: N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide dihydrochloride

InChi Key: ZQBNWMFBOSOOLX-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H27N3O3S.2ClH/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27;;/h3-9,18,23H,10-15H2,1-2H3;2*1H

SMILES Code: CS(=O)(NC1=CC=C(C(C2CCN(CCC3=NC(C)=CC=C3)CC2)=O)C=C1)=O.[H]Cl.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Chan AP, Leung MW, So PP, Guppy LJ, Walker MJ. Effects of E4031 and quinidine on atrial and ventricular refractoriness in rabbits in vivo. Proc West Pharmacol Soc. 2004;47:39-41. PubMed PMID: 15633608.

2: Webster R, Allan G, Anto-Awuakye K, Harrison A, Kidd T, Leishman D, Phipps J, Walker D. Pharmacokinetic/pharmacodynamic assessment of the effects of E4031, cisapride, terfenadine and terodiline on monophasic action potential duration in dog. Xenobiotica. 2001 Aug-Sep;31(8-9):633-50. PubMed PMID: 11569530.

3: Shiroshita-Takeshita A, Mitamura H, Sato T, Shinagawa K, Kurita Y, Kanki H, Takatsuki S, Hara M, Ogawa S. Preserved effects of potassium channel blockers in the pacing-induced remodeled canine atrium: a comparison between E4031 and azimilide. J Cardiovasc Pharmacol. 2003 May;41(5):678-85. PubMed PMID: 12717097.