Memogain

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MedKoo CAT#: 527601

CAS#: 224169-27-1

Description: Memogain, also known as GLN-1062, is an acetylcholinesterase (AChE) inhibitor potentially for the treatment of Alzheimer's disease. Memogain, a pro-drug, liberates galantamine on cleavage by a carboxyesterase in the brain. Memogain has more than 15-fold higher bioavailability in the brain than the same doses of galantamine. In the brain, Memogain is enzymatically cleaved to galantamine, thereby regaining its pharmacological activity as a cholinergic enhancer.

Chemical Structure

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Memogain
CAS# 224169-27-1
Instruction

Theoretical Analysis

MedKoo Cat#: 527601
Name: Memogain
CAS#: 224169-27-1
Chemical Formula: C24H25NO4
Exact Mass: 391.18
Molecular Weight: 391.467
Elemental Analysis: C, 73.64; H, 6.44; N, 3.58; O, 16.35

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Benzgalantamine; Memogain; GLN-1062; GLN-1062; GLN-1062

IUPAC/Chemical Name: (4aS,6R,8aS)-3-methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-yl benzoate

InChi Key: JKVNJTYHRABHIY-WXVUKLJWSA-N

InChi Code: InChI=1S/C24H25NO4/c1-25-13-12-24-11-10-18(28-23(26)16-6-4-3-5-7-16)14-20(24)29-22-19(27-2)9-8-17(15-25)21(22)24/h3-11,18,20H,12-15H2,1-2H3/t18-,20-,24-/m0/s1

SMILES Code: CN1CC[C@]23C4=C(O[C@@]2([H])C[C@@H](OC(C5=CC=CC=C5)=O)C=C3)C(OC)=CC=C4C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 391.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bhattacharya S, Maelicke A, Montag D. Nasal Application of the Galantamine Pro-drug Memogain Slows Down Plaque Deposition and Ameliorates Behavior in 5X Familial Alzheimer's Disease Mice. J Alzheimers Dis. 2015;46(1):123-36. doi: 10.3233/JAD-142421. PubMed PMID: 25720404.

2: Maelicke A, Hoeffle-Maas A, Ludwig J, Maus A, Samochocki M, Jordis U, Koepke AK. Memogain is a galantamine pro-drug having dramatically reduced adverse effects and enhanced efficacy. J Mol Neurosci. 2010 Jan;40(1-2):135-7. doi: 10.1007/s12031-009-9269-5. PubMed PMID: 19669943.