NCX-6560

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527522

CAS#: 803728-45-2

Description: NCX-6560 is a HMG-CoA reductase inhibitor and nitric oxide donor potentially for the treatment of atherosclerosis and dyslipidemia. NCX-6560 reduced portal pressure without changing systemic hemodynamics. NCX-6560 induced a higher intrahepatic vasoprotective profile. NCX-6560 eliminated hepatic toxicity and reduced muscular toxicity caused by atorvastatin.


Chemical Structure

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NCX-6560
CAS# 803728-45-2

Theoretical Analysis

MedKoo Cat#: 527522
Name: NCX-6560
CAS#: 803728-45-2
Chemical Formula: C37H42FN3O8
Exact Mass: 675.30
Molecular Weight: 675.754
Elemental Analysis: C, 65.76; H, 6.26; F, 2.81; N, 6.22; O, 18.94

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: NCX-6560; NCX 6560; NCX6560

IUPAC/Chemical Name: 4-(nitrooxy)butyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

InChi Key: QBBIDMMGINYIJJ-FIRIVFDPSA-N

InChi Code: InChI=1S/C37H42FN3O8/c1-25(2)35-34(37(45)39-29-13-7-4-8-14-29)33(26-11-5-3-6-12-26)36(27-15-17-28(38)18-16-27)40(35)20-19-30(42)23-31(43)24-32(44)48-21-9-10-22-49-41(46)47/h3-8,11-18,25,30-31,42-43H,9-10,19-24H2,1-2H3,(H,39,45)/t30-,31-/m1/s1

SMILES Code: O=C(C1=C(C(C)C)N(CC[C@H](C[C@H](CC(OCCCCO[N+]([O-])=O)=O)O)O)C(C2=CC=C(F)C=C2)=C1C3=CC=CC=C3)NC4=CC=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 675.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Momi S, Impagnatiello F, Guzzetta M, Caracchini R, Guglielmini G, Olivieri R, Monopoli A, Gresele P. NCX 6560, a nitric oxide-releasing derivative of atorvastatin, inhibits cholesterol biosynthesis and shows anti-inflammatory and anti-thrombotic properties. Eur J Pharmacol. 2007 Sep 10;570(1-3):115-24. PubMed PMID: 17632098.

2: Rodríguez S, Raurell I, Torres-Arauz M, García-Lezana T, Genescà J, Martell M. A Nitric Oxide-Donating Statin Decreases Portal Pressure with a Better Toxicity Profile than Conventional Statins in Cirrhotic Rats. Sci Rep. 2017 Jan 13;7:40461. doi: 10.1038/srep40461. PubMed PMID: 28084470; PubMed Central PMCID: PMC5233977.

3: Baetta R, Granata A, Miglietta D, Oliva F, Arnaboldi L, Bonomo A, Ferri N, Ongini E, Bellosta S, Corsini A. Nitric oxide-donating atorvastatin attenuates neutrophil recruitment during vascular inflammation independent of changes in plasma cholesterol. Cardiovasc Drugs Ther. 2013 Jun;27(3):211-9. doi: 10.1007/s10557-013-6445-1. PubMed PMID: 23400638.

4: D'Antona G, Mascaro A, Monopoli A, Miglietta D, Ongini E, Bottinelli R. Nitric oxide prevents atorvastatin-induced skeletal muscle dysfunction and alterations in mice. Muscle Nerve. 2013 Jan;47(1):72-80. doi: 10.1002/mus.23465. PubMed PMID: 23042511.

5: Momi S, Monopoli A, Alberti PF, Falcinelli E, Corazzi T, Conti V, Miglietta D, Ongini E, Minuz P, Gresele P. Nitric oxide enhances the anti-inflammatory and anti-atherogenic activity of atorvastatin in a mouse model of accelerated atherosclerosis. Cardiovasc Res. 2012 Jun 1;94(3):428-38. doi: 10.1093/cvr/cvs100. PubMed PMID: 22362817.

6: Drechsler M, Soehnlein O, Weber C. Nitric oxide-donating statins upgrade the benefits of lipid-lowering in vascular inflammation by desensitizing neutrophil activation: editorial to: "Nitric oxide-donating atorvastatin attenuates neutrophil recruitment during vascular inflammation independent of changes in plasma cholesterol" by R. Baetta et al. Cardiovasc Drugs Ther. 2013 Jun;27(3):183-5. doi: 10.1007/s10557-013-6452-2. PubMed PMID: 23440356.