CV-1808
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MedKoo CAT#: 531755

CAS#: 53296-10-9

Description: CV-1808 is an adenosine A2 receptor agonist that acts as a coronary vasodilator, antihypertensive and antipsychotic following systemic administration in vivo.


Chemical Structure

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CV-1808
CAS# 53296-10-9

Theoretical Analysis

MedKoo Cat#: 531755
Name: CV-1808
CAS#: 53296-10-9
Chemical Formula: C16H18N6O4
Exact Mass: 358.14
Molecular Weight: 358.360
Elemental Analysis: C, 53.63; H, 5.06; N, 23.45; O, 17.86

Price and Availability

Size Price Availability Quantity
5mg USD 220
10mg USD 350
25mg USD 425
50mg USD 705
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Synonym: 2-Phenylaminoadenosine, CV-1808; CV 1808; CV1808.

IUPAC/Chemical Name: (2R,3R,4S,5R)-2-[6-amino-2-(phenylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

InChi Key: SCNILGOVBBRMBK-SDBHATRESA-N

InChi Code: InChI=1S/C16H18N6O4/c17-13-10-14(21-16(20-13)19-8-4-2-1-3-5-8)22(7-18-10)15-12(25)11(24)9(6-23)26-15/h1-5,7,9,11-12,15,23-25H,6H2,(H3,17,19,20,21)/t9-,11-,12-,15-/m1/s1

SMILES Code: O[C@H]1[C@H](N2C=NC3=C(N)N=C(NC4=CC=CC=C4)N=C23)O[C@H](CO)[C@H]1O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 358.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cornfield LJ, Hu S, Hurt SD, Sills MA. [3H]2-phenylaminoadenosine ([3H]CV 1808) labels a novel adenosine receptor in rat brain. J Pharmacol Exp Ther. 1992 Nov;263(2):552-61. PubMed PMID: 1331404.

2: Hardart GE, Sullivan GW, Carper HT, Mandell GL. Adenosine and 2-phenylaminoadenosine (CV-1808) inhibit human neutrophil bactericidal function. Infect Immun. 1991 Mar;59(3):885-9. PubMed PMID: 1847698; PubMed Central PMCID: PMC258343.

3: Tanabe M, Terashita Z, Nishikawa K, Hirata M. Inhibition of coronary circulatory failure and thromboxane A2 release during coronary occlusion and reperfusion by 2-phenylaminoadenosine (CV-1808) in anesthetized dogs. J Cardiovasc Pharmacol. 1984 May-Jun;6(3):442-8. PubMed PMID: 6202970.

4: Taylor DA, Williams M. Interaction of 2-phenylaminoadenosine (CV 1808) with adenosine systems in rat tissues. Eur J Pharmacol. 1982 Dec 3;85(3-4):335-8. PubMed PMID: 6295788.

5: Hayashi Y, Miyake S, Kuwayama M, Hattori M, Usui Y. Quantitation of 6-amino-2-phenylamino-9-beta-D-ribofuranosyl-9-H-purine (CV-1808) and its metabolite, 2-(2-hydroxyphenyl)aminoadenosine, in human serum and urine by high performance liquid chromatography using a fluorimetric detector. Chem Pharm Bull (Tokyo). 1982 Nov;30(11):4107-13. PubMed PMID: 7165879.

6: Matsumoto N, Kawazoe K, Tanabe M, Imamoto T, Fujiwara S, Hirata M. Effect of 2-phenylaminoadenosine (CV-1808) on ischemic ST-segment elevation in anesthetized dogs. J Cardiovasc Pharmacol. 1981 Nov-Dec;3(6):1184-92. PubMed PMID: 6173517.

7: Kawazoe K, Matsumoto N, Tanabe M, Fujiwara S, Yanagimoto M, Hirata M, Kikuchi K. Coronary and cardiohemodynamic effects of 2-phenylamino-adenosine (CV-1808) in anesthetized dogs and cats. Arzneimittelforschung. 1980;30(7):1083-7. PubMed PMID: 7191290.