Sulcardine sulfate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 529526

CAS#: 343935-61-5 (sulfate)

Description: Sulcardine sulfate is a multi-ion channel blocker potentially for the treatment of arrhythmia.

Chemical Structure

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Sulcardine sulfate
CAS# 343935-61-5 (sulfate)
Instruction

Theoretical Analysis

MedKoo Cat#: 529526
Name: Sulcardine sulfate
CAS#: 343935-61-5 (sulfate)
Chemical Formula: C24H35N3O8S2
Exact Mass: 0.00
Molecular Weight: 557.670
Elemental Analysis: C, 51.69; H, 6.33; N, 7.54; O, 22.95; S, 11.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 343935-60-4 (free base)   343935-61-5 (sulfate)   934843-86-4 (sulfate trihydrate)  

Synonym: B-87823; HBI-3000; B87823; HBI3000; B 87823; HBI 3000

IUPAC/Chemical Name: N-(4-hydroxy-3,5-bis(pyrrolidin-1-ylmethyl)benzyl)-4-methoxybenzenesulfonamide sulfate

InChi Key: BQCSIJGCWZAHPG-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H33N3O4S.H2O4S/c1-31-22-6-8-23(9-7-22)32(29,30)25-16-19-14-20(17-26-10-2-3-11-26)24(28)21(15-19)18-27-12-4-5-13-27;1-5(2,3)4/h6-9,14-15,25,28H,2-5,10-13,16-18H2,1H3;(H2,1,2,3,4)

SMILES Code: O=S(C1=CC=C(OC)C=C1)(NCC2=CC(CN3CCCC3)=C(O)C(CN4CCCC4)=C2)=O.O=S(O)(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 557.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wang W, Qian HJ, Xin L, Zhang MQ, Lu DY, Jin JM, Liu GY, Jia JY, Zheng HC, Yu C, Wang YP, Zhu F, Liu Y. Multiple Dose Pharmacokinetics and Safety of Sulcardine Sulfate in Healthy Chinese Male Subjects: An Open-Label Phase I Clinical Study. Eur J Drug Metab Pharmacokinet. 2016 Aug 22. [Epub ahead of print] PubMed PMID: 27550655.

2: Jia J, Liu G, Zhang M, Lu Y, Lu C, Liu Y, Zheng H, Wang W, Gui Y, Yu C, Li S, Wang Y. Determination of the novel antiarrhythmic drug sulcardine sulfate in human plasma by liquid chromatography tandem mass spectrometry and its application in a clinical pharmacokinetic study. Biomed Chromatogr. 2016 Aug;30(8):1291-6. doi: 10.1002/bmc.3681. PubMed PMID: 26715470.

3: Chen Q, Qian HJ, Wang W, Zhang MQ, Lu DY, Lu C, Jin JM, Hu CY, Liu GY, Jia JY, Zheng HC, Li XN, Yu C, Wang YP, Liu Y. Pharmacokinetics, safety, and tolerability of sulcardine sulfate: an open-label, single-dose, randomized study in healthy Chinese subjects. Fundam Clin Pharmacol. 2017 Feb;31(1):120-125. doi: 10.1111/fcp.12242. PubMed PMID: 27599871.

4: Lu YL, Li SJ, Liu GY, Li XC, Yang D, Jia JY, Zhang MQ, Zheng HC, Yu C, Zhu F, Wang YP. Oral Bioavailability and Mass Balance Studies of a Novel Anti-arrhythmic Agent Sulcardine Sulfate in Sprague-Dawley Rats and Beagle Dogs. Eur J Drug Metab Pharmacokinet. 2016 Jul 11. [Epub ahead of print] PubMed PMID: 27402487.

5: Lee JY, Lucchesi BR. HBI-3000 prevents secondary sudden cardiac death. J Cardiovasc Pharmacol Ther. 2013 Sep;18(5):453-9. doi: 10.1177/1074248413485433. PubMed PMID: 23615576.

6: Bai DL, Chen WZ, Bo YX, Dong YL, Kang AL, Sun WK, Wang W, Hu ZL, Wang YP. Discovery of N-(3,5-bis(1-pyrrolidylmethyl)-4-hydroxybenzyl)-4-methoxybenzenesulfamide (sulcardine) as a novel anti-arrhythmic agent. Acta Pharmacol Sin. 2012 Sep;33(9):1176-86. doi: 10.1038/aps.2012.119. PubMed PMID: 22922342; PubMed Central PMCID: PMC4003109.

7: Guo D, Liu Q, Liu T, Elliott G, Gingras M, Kowey PR, Yan GX. Electrophysiological properties of HBI-3000: a new antiarrhythmic agent with multiple-channel blocking properties in human ventricular myocytes. J Cardiovasc Pharmacol. 2011 Jan;57(1):79-85. doi: 10.1097/FJC.0b013e3181ffe8b3. PubMed PMID: 20980921.