WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531570

CAS#: 917896-43-6

Description: BHF-177 is a positive allosteric modulator at the GABAB receptor. It was shown to reduce self-administration of nicotine in animal studies.

Price and Availability




BHF-177, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 531570
Name: BHF-177
CAS#: 917896-43-6
Chemical Formula: C19H20F3N3
Exact Mass: 347.1609
Molecular Weight: 347.39
Elemental Analysis: C, 65.69; H, 5.80; F, 16.41; N, 12.10

Synonym: BHF-177; BHF 177; BHF177.

IUPAC/Chemical Name: N-[(1R,2R,4S)-bicyclo[2.2.1]heptan-2-yl]-2-methyl-5-[4-(trifluoromethyl)phenyl]pyrimidin-4-amine


InChi Code: InChI=1S/C19H20F3N3/c1-11-23-10-16(13-4-6-15(7-5-13)19(20,21)22)18(24-11)25-17-9-12-2-3-14(17)8-12/h4-7,10,12,14,17H,2-3,8-9H2,1H3,(H,23,24,25)/t12-,14+,17+/m0/s1

SMILES Code: FC(C1=CC=C(C2=CN=C(C)N=C2N[C@H]3[C@](C4)([H])CC[C@]4([H])C3)C=C1)(F)F

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Li X, Kaczanowska K, Finn MG, Markou A, Risbrough VB. The GABA(B) receptor positive modulator BHF177 attenuated anxiety, but not conditioned fear, in rats. Neuropharmacology. 2015 Oct;97:357-64. doi: 10.1016/j.neuropharm.2015.05.001. PubMed PMID: 26002628; PubMed Central PMCID: PMC4537349.

2: Li X, Risbrough VB, Cates-Gatto C, Kaczanowska K, Finn MG, Roberts AJ, Markou A. Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice. Neuropharmacology. 2013 Jul;70:156-67. doi: 10.1016/j.neuropharm.2013.01.018. PubMed PMID: 23376712; PubMed Central PMCID: PMC3644349.

3: Orrù A, Fujani D, Cassina C, Conti M, Di Clemente A, Cervo L. Operant, oral alcoholic beer self-administration by C57BL/6J mice: effect of BHF177, a positive allosteric modulator of GABA(B) receptors. Psychopharmacology (Berl). 2012 Aug;222(4):685-700. doi: 10.1007/s00213-012-2672-6. PubMed PMID: 22411427.

4: Vlachou S, Guery S, Froestl W, Banerjee D, Benedict J, Finn MG, Markou A. Repeated administration of the GABAB receptor positive modulator BHF177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in rats. Psychopharmacology (Berl). 2011 May;215(1):117-28. doi: 10.1007/s00213-010-2119-x. PubMed PMID: 21181127; PubMed Central PMCID: PMC3072487.