TA-270

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 529611

CAS#: 194037-25-7

Description: TA-720, also known as LS-123351, is a 5-lipoxygenase inhibitor potentially for the treatment of asthma.


Price and Availability

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Price

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TA-270 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 529611
Name: TA-270
CAS#: 194037-25-7
Chemical Formula: C29H36N2O7
Exact Mass: 524.2523
Molecular Weight: 524.61
Elemental Analysis: C, 66.40; H, 6.92; N, 5.34; O, 21.35


Synonym: TA-270; TA270; TA 270; LS-123351; LS123351; LS123351

IUPAC/Chemical Name: (E)-N-(4-hydroxy-1-methyl-3-(octyloxy)-2-oxo-1,2-dihydroquinolin-7-yl)-3-(4-hydroxy-3,5-dimethoxyphenyl)acrylamide

InChi Key: SZNJINHODJLULD-SDNWHVSQSA-N

InChi Code: InChI=1S/C29H36N2O7/c1-5-6-7-8-9-10-15-38-28-26(33)21-13-12-20(18-22(21)31(2)29(28)35)30-25(32)14-11-19-16-23(36-3)27(34)24(17-19)37-4/h11-14,16-18,33-34H,5-10,15H2,1-4H3,(H,30,32)/b14-11+

SMILES Code: O=C(NC1=CC2=C(C=C1)C(O)=C(OCCCCCCCC)C(N2C)=O)/C=C/C3=CC(OC)=C(O)C(OC)=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information


References

1: Mizutani N, Aoki Y, Nabe T, Ishiwara M, Yoshino S, Takagaki H, Kohno S. Effect of TA-270, a novel quinolinone derivative, on antigen-induced nasal blockage in a guinea pig model of allergic rhinitis. Eur J Pharmacol. 2009 Jan 5;602(1):138-42. doi: 10.1016/j.ejphar.2008.11.006. PubMed PMID: 19022242.

2: Ishiwara M, Aoki Y, Takagaki H, Ui M, Okajima F. TA-270 [4-hydroxy-1-methyl-3-octyloxy-7-sinapinoylamino-2(1H)-quinolinone], an anti-asthmatic agent, inhibits leukotriene production induced by IgE receptor stimulation in RBL-2H3 cells. J Pharmacol Exp Ther. 2003 Nov;307(2):583-8. PubMed PMID: 12970384.

3: Kimura N, Fukui H, Takagaki H, Yonemochi E, Terada K. Characterization of polymorphs of a novel quinolinone derivative, TA-270 (4-hydroxy-1-methyl-3-octyloxy-7-sinapinoylamino-2(1H)-quinolinone). Chem Pharm Bull (Tokyo). 2001 Oct;49(10):1321-5. PubMed PMID: 11605662.

4: Aoki Y, Ishiwara M, Koda A, Takagaki H. Inhibitory effect of a novel quinolinone derivative, TA-270, on asthmatic inflammatory responses in sensitized guinea pigs. Eur J Pharmacol. 2000 Dec 15;409(3):325-30. PubMed PMID: 11108828.

5: Kamat SK, Barde PJ, Raut SB. Evaluation of the estrogenic activity of Indian medicinal plants in immature rats. Anc Sci Life. 2015 Oct-Dec;35(2):90-5. doi: 10.4103/0257-7941.171669. PubMed PMID: 26865741; PubMed Central PMCID: PMC4728870.

6: Panteleon V, Kostakis IK, Marakos P, Pouli N, Andreadou I. Synthesis of some new spiropyranoquinolines and evaluation of their free radical scavenging activity. Chem Pharm Bull (Tokyo). 2009 May;57(5):446-52. PubMed PMID: 19420773.