WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 531499
Description: UMB-68 is a GHB receptor ligand. UMB68 showed no affinity (IC(50) >100 microM) at GABA(A) or GABA(B) receptors. In vivo studies showed that, at behaviorally active doses, rats trained to discriminate GHB did not recognize the novel ligands as GHB. Thus, UMB68 is a selective GHB receptor ligand in binding assays, will not undergo metabolism to GABA-active compounds, and does not show the same effects as GHB in vivo. These data suggest that, although UMB68 binds to the GHB receptor, it does not have the observed GABA receptor-mediated effects of GHB in vivo and could provide a novel tool for studying the pharmacology of the GHB receptor in the absence of complicating GABAergic effects.
MedKoo Cat#: 531499
Name: UMB-68 sodium
Chemical Formula: C6H11NaO3
Molecular Weight: 154.1408
Elemental Analysis: C, 46.75; H, 7.19; Na, 14.91; O, 31.14
Synonym: UMB68, UMB-68, UMB 68, UMB-68 sodium
IUPAC/Chemical Name: Sodium 4-Hydroxy-4-methylpentanoate
InChi Key: RKKDHFJDHVHVLY-UHFFFAOYSA-M
InChi Code: InChI=1S/C6H12O3.Na/c1-6(2,9)4-3-5(7)8;/h9H,3-4H2,1-2H3,(H,7,8);/q;+1/p-1
SMILES Code: CC(C)(O)CCC([O-])=O.[Na+]
γ-Hydroxybutyric acid (GHB) is an endogenous compound in the mammalian brain with both low- and high-affinity receptor targets. GHB is used clinically in the treatment of symptoms of narcolepsy and alcoholism, but also illicitly abused as the recreational drug Fantasy.
1: Bay T, Eghorn LF, Klein AB, Wellendorph P. GHB receptor targets in the CNS: focus on high-affinity binding sites. Biochem Pharmacol. 2014 Jan 15;87(2):220-8. doi: 10.1016/j.bcp.2013.10.028. Review. PubMed PMID: 24269284.
2: Wu H, Zink N, Carter LP, Mehta AK, Hernandez RJ, Ticku MK, Lamb R, France CP, Coop A. A tertiary alcohol analog of gamma-hydroxybutyric acid as a specific gamma-hydroxybutyric acid receptor ligand. J Pharmacol Exp Ther. 2003 May;305(2):675-9. PubMed PMID: 12606613.