SUN-1334H (HCl)

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MedKoo CAT#: 529710

CAS#: 607736-84-5 (HCl)

Description: SUN-1334H is a histamine H1 receptor antagonist potentially for the treatment of allergic conjunctivitis and allergic rhinitis

Chemical Structure

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SUN-1334H (HCl)
CAS# 607736-84-5 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 529710
Name: SUN-1334H (HCl)
CAS#: 607736-84-5 (HCl)
Chemical Formula: C23H28Cl2F2N2O3
Exact Mass: 0.00
Molecular Weight: 489.380
Elemental Analysis: C, 56.45; H, 5.77; Cl, 14.49; F, 7.76; N, 5.72; O, 9.81

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 607737-00-8 (free base)   607736-84-5 (HCl)  

Synonym: 1334H; SUN-1334H; SUN 1334H;

IUPAC/Chemical Name: (E)-2-((4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)but-2-en-1-yl)oxy)acetic acid dihydrochloride

InChi Key: KAQMKGKFTBFMGE-SEPHDYHBSA-N

InChi Code: InChI=1S/C23H26F2N2O3.2ClH/c24-20-7-3-18(4-8-20)23(19-5-9-21(25)10-6-19)27-14-12-26(13-15-27)11-1-2-16-30-17-22(28)29;;/h1-10,23H,11-17H2,(H,28,29);2*1H/b2-1+;;

SMILES Code: O=C(O)COC/C=C/CN1CCN(C(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CC1.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 489.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Mandhane SN, Shah JH, Bahekar PC, Mehetre SV, Pawar CA, Bagad AS, Chidrewar GU, Rao CT, Rajamannar T. Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel antihistamine SUN-1334H. Int Arch Allergy Immunol. 2010;151(1):56-69. doi: 10.1159/000232571. PubMed PMID: 19672097.

2: Mandhane SN, Ayer UB, Midha AS, Rao CT, Rajamannar T. Preclinical efficacy and safety pharmacology of SUN-1334H, a potent orally active antihistamine agent. Drugs R D. 2008;9(2):93-112. PubMed PMID: 18298128.