Nitidine chloride
featured

Orders received during 11/25~11/29 will be shipped in 11/30/2020 due to Thanksgiving holiday.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407364

CAS#: 13063-04-2 (chloride)

Description: Nitidine is a benzophenanthridine alkaloid found in species of the genus Zanthoxylum , notably in Zanthoxylum nitidum. This compound has an anti-malarial activity. Nitidine increased CNS tissue sparing and improved functional recovery by attenuating reactive microgliosis, suggestive of the potential therapeutic benefit for CNS injury. Nitidine chloride induces apoptosis and inhibits tumor cell proliferation via suppressing ERK signaling pathway in renal cancer. Nitidine chloride inhibits renal cancer cell metastasis via suppressing AKT signaling pathway. Nitidine chloride inhibits ovarian cancer cell migration and invasion by suppressing MMP-2/9 production via the ERK signaling pathway. Nitidine chloride induces apoptosis, cell cycle arrest, and synergistic cytotoxicity with doxorubicin in breast cancer cells.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 240 2 Weeks
25mg USD 610 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-11-25. Prices are subject to change without notice.

Nitidine chloride, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 407364
Name: Nitidine chloride
CAS#: 13063-04-2 (chloride)
Chemical Formula: C21H18ClNO4
Exact Mass:
Molecular Weight: 383.828
Elemental Analysis: C, 65.71; H, 4.73; Cl, 9.24; N, 3.65; O, 16.67


Related CAS #: 6872-57-7 (Nitidine cation); 13063-04-2 (chloride)  

Synonym: Nitidine; NSC 146397; NSC-146397; NSC146397.

IUPAC/Chemical Name: (1,3)-Benzodioxolo(5,6-c)phenanthridinium, 2,3-dimethoxy-12-methyl-, chloride

InChi Key: QLDAACVSUMUMOR-UHFFFAOYSA-M

InChi Code: InChI=1S/C21H18NO4.ClH/c1-22-10-13-7-17(23-2)18(24-3)8-15(13)14-5-4-12-6-19-20(26-11-25-19)9-16(12)21(14)22;/h4-10H,11H2,1-3H3;1H/q+1;/p-1

SMILES Code: C[N+]1=CC2=CC(OC)=C(OC)C=C2C(C=CC3=C4)=C1C3=CC5=C4OCO5.[Cl-]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Yuan Y, Zhu F, Pu Y, Wang D, Huang A, Hu X, Qin S, Sun X, Su Z, He C. Neuroprotective effects of nitidine against traumatic CNS injury via inhibiting microglia activation. Brain Behav Immun. 2015 Aug;48:287-300. doi: 10.1016/j.bbi.2015.04.008. PubMed PMID: 25900440.

2: Bouquet J, Rivaud M, Chevalley S, Deharo E, Jullian V, Valentin A. Biological activities of nitidine, a potential anti-malarial lead compound. Malar J. 2012 Mar 9;11:67. doi: 10.1186/1475-2875-11-67. PubMed PMID: 22404785; PubMed Central PMCID: PMC3325168.

3: Praveena C, Veeresham C. Multiple shoot regeneration and effect of sugars on growth and nitidine accumulation in shoot cultures of Toddalia asiatica. Pharmacogn Mag. 2014 Aug;10(Suppl 3):S480-6. doi: 10.4103/0973-1296.139777. PubMed PMID: 25298663; PubMed Central PMCID: PMC4189261.

4: Chen J, Wang J, Lin L, He L, Wu Y, Zhang L, Yi Z, Chen Y, Pang X, Liu M. Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer. Mol Cancer Ther. 2012 Feb;11(2):277-87. doi: 10.1158/1535-7163.MCT-11-0648. PubMed PMID: 22203730.

5: Xu Q, Li ZX, Ye ZM. [Nitidine chloride-induced apoptosis of human osteosarcoma cells and its mechanism]. Nan Fang Yi Ke Da Xue Xue Bao. 2011 Feb;31(2):361-4. Chinese. PubMed PMID: 21354931.

6: Cesari I, Grisoli P, Paolillo M, Milanese C, Massolini G, Brusotti G. Isolation and characterization of the alkaloid Nitidine responsible for the traditional use of Phyllanthus muellerianus (Kuntze) Excell stem bark against bacterial infections. J Pharm Biomed Anal. 2015 Feb;105:115-20. doi: 10.1016/j.jpba.2014.11.051. PubMed PMID: 25546028.

7: Li Y, Zhang Z, Zhang Y, Deng D, Luo L, Han B, Fan C. Nitidine chloride-assisted bio-functionalization of reduced graphene oxide by bovine serum albumin for impedimetric immunosensing. Biosens Bioelectron. 2016 May 15;79:536-42. doi: 10.1016/j.bios.2015.12.076. PubMed PMID: 26748371.

8: Liu H, Ye D, Huang H, Wang X, Li D. [Studies on pharmacokinetics of nitidine chloride in rabbits]. Zhongguo Zhong Yao Za Zhi. 2009 Jun;34(11):1406-9. Chinese. PubMed PMID: 19771873.

9: Fang Z, Tang Y, Jiao W, Xing Z, Guo Z, Wang W, Xu Z, Liu Z. Nitidine chloride induces apoptosis and inhibits tumor cell proliferation via suppressing ERK signaling pathway in renal cancer. Food Chem Toxicol. 2014 Apr;66:210-6. doi: 10.1016/j.fct.2014.01.049. PubMed PMID: 24508476.

10: Fang Z, Tang Y, Jiao W, Xing Z, Guo Z, Wang W, Shi B, Xu Z, Liu Z. Nitidine chloride inhibits renal cancer cell metastasis via suppressing AKT signaling pathway. Food Chem Toxicol. 2013 Oct;60:246-51. doi: 10.1016/j.fct.2013.07.062. PubMed PMID: 23911800.

11: Wang Z, Jiang W, Zhang Z, Qian M, Du B. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells. J Ethnopharmacol. 2012 Oct 31;144(1):145-50. doi: 10.1016/j.jep.2012.08.041. PubMed PMID: 22971898.

12: Jia CP, Feng F. Optimization of the separation and determination of nitidine and chelerythrine in Zanthoxylum nitidum by high-performance liquid chromatography with fluorescence detection. J Chromatogr Sci. 2014 Feb;52(2):164-8. doi: 10.1093/chromsci/bmt003. PubMed PMID: 23390024.

13: Sun X, Lin L, Chen Y, Liu T, Liu R, Wang Z, Mou K, Xu J, Li B, Song H. Nitidine chloride inhibits ovarian cancer cell migration and invasion by suppressing MMP-2/9 production via the ERK signaling pathway. Mol Med Rep. 2016 Apr;13(4):3161-8. doi: 10.3892/mmr.2016.4929. PubMed PMID: 26935265.

14: Zhai H, Hu S, Liu T, Wang F, Wang X, Wu G, Zhang Y, Sui M, Liu H, Jiang L. Nitidine chloride inhibits proliferation and induces apoptosis in colorectal cancer cells by suppressing the ERK signaling pathway. Mol Med Rep. 2016 Mar;13(3):2536-42. doi: 10.3892/mmr.2016.4827. PubMed PMID: 26847477; PubMed Central PMCID: PMC4768981.

15: Ou X, Lu Y, Liao L, Li D, Liu L, Liu H, Xu H. Nitidine chloride induces apoptosis in human hepatocellular carcinoma cells through a pathway involving p53, p21, Bax and Bcl-2. Oncol Rep. 2015 Mar;33(3):1264-74. doi: 10.3892/or.2014.3688. PubMed PMID: 25530218.

16: Liu N, Li P, Zang S, Liu Q, Ma D, Sun X, Ji C. Novel agent nitidine chloride induces erythroid differentiation and apoptosis in CML cells through c-Myc-miRNAs axis. PLoS One. 2015 Feb 3;10(2):e0116880. doi: 10.1371/journal.pone.0116880. PubMed PMID: 25647305; PubMed Central PMCID: PMC4315404.

17: Sun M, Zhang N, Wang X, Cai C, Cun J, Li Y, Lv S, Yang Q. Nitidine chloride induces apoptosis, cell cycle arrest, and synergistic cytotoxicity with doxorubicin in breast cancer cells. Tumour Biol. 2014 Oct;35(10):10201-12. doi: 10.1007/s13277-014-2327-9. PubMed PMID: 25027404.

18: Lin J, Shen A, Chen H, Liao J, Xu T, Liu L, Lin J, Peng J. Nitidine chloride inhibits hepatic cancer growth via modulation of multiple signaling pathways. BMC Cancer. 2014 Sep 30;14:729. doi: 10.1186/1471-2407-14-729. PubMed PMID: 25266147; PubMed Central PMCID: PMC4190448.

19: Li L, Tu M, Yang X, Sun S, Wu X, Zhou H, Zeng S, Jiang H. The contribution of human OCT1, OCT3, and CYP3A4 to nitidine chloride-induced hepatocellular toxicity. Drug Metab Dispos. 2014 Jul;42(7):1227-34. doi: 10.1124/dmd.113.056689. PubMed PMID: 24778366.

20: Kang M, Ou H, Wang R, Liu W, Tang A. The effect of nitidine chloride on the proliferation and apoptosis of nasopharyngeal carcinoma cells. J BUON. 2014 Jan-Mar;19(1):130-6. PubMed PMID: 24659654.