S39625

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407362

CAS#: 536711-20-3

Description: S39625 is an E-ring camptothecin keto analogue. S39625 is stable, potent, and selective topoisomerase I inhibitor without being substrates of drug efflux transporters. Nanomolar concentrations of S39625 induces intense and persistent histone gamma-H2AX. The chemical stability of the keto analogues and the ability of S39625 to produce high levels of persistent Top1-DNA cleavage complex and its potent antiproliferative activity against human cancer cell lines make S39625 a promising new anticancer drug candidate. Histone gamma-H2AX could be used as a biomarker for the upcoming clinical trials of S39625.


Price and Availability

Size
Price

Size
Price

Size
Price

S39625 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 407362
Name: S39625
CAS#: 536711-20-3
Chemical Formula: C25H22N2O5
Exact Mass: 430.1529
Molecular Weight: 430.46
Elemental Analysis: C, 69.76; H, 5.15; N, 6.51; O, 18.58


Synonym: S39625; S-39625; S 39625.

IUPAC/Chemical Name: (S)-13-cyclobutyl-7-ethyl-7-hydroxy-9,12-dihydro-7H-cyclopenta[6,7]indolizino[1,2-b][1,3]dioxolo[4,5-g]quinoline-8,10-dione

InChi Key: BSNSKRNANVCWQN-VWLOTQADSA-N

InChi Code: InChI=1S/C25H22N2O5/c1-2-25(30)16-8-18-23-15(10-27(18)24(29)13(16)7-21(25)28)22(12-4-3-5-12)14-6-19-20(32-11-31-19)9-17(14)26-23/h6,8-9,12,30H,2-5,7,10-11H2,1H3/t25-/m0/s1

SMILES Code: O=C(C1)[C@](O)(CC)C2=C1C(N3CC4=C(C5CCC5)C6=CC(OCO7)=C7C=C6N=C4C3=C2)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Takagi K, Dexheimer TS, Redon C, Sordet O, Agama K, Lavielle G, Pierré A,
Bates SE, Pommier Y. Novel E-ring camptothecin keto analogues (S38809 and S39625)
are stable, potent, and selective topoisomerase I inhibitors without being
substrates of drug efflux transporters. Mol Cancer Ther. 2007 Dec;6(12 Pt
1):3229-38. PubMed PMID: 18089716.