RTI-371

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MedKoo CAT#: 530476

CAS#: 652978-45-5

Description: RTI-371, also known as RTI-4229-371, is a potent and selective dopamine reuptake inhibitor in vitro. RTI-371 and several other DAT-selective inhibitors with atypical actions on locomotor behaviour increased the efficacy of CP55940 in a concentration-dependent manner.


Chemical Structure

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RTI-371
CAS# 652978-45-5

Theoretical Analysis

MedKoo Cat#: 530476
Name: RTI-371
CAS#: 652978-45-5
Chemical Formula: C24H25ClN2O
Exact Mass: 392.17
Molecular Weight: 392.927
Elemental Analysis: Chemical Formula: C24H25ClN2O Exact Mass: 392.1655 Molecular Weight: 392.9270 Elemental Analysis: C, 73.36; H, 6.41; Cl, 9.02; N, 7.13; O, 4.07

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: RTI-4229-371; RTI 4229-371; RTI4229-371; RTI-371; RTI371; RTI 371.

IUPAC/Chemical Name: 3-(4-chlorophenyl)-5-((1S,2S,3S,5R)-8-methyl-3-(p-tolyl)-8-azabicyclo[3.2.1]octan-2-yl)isoxazole

InChi Key: MUVQRHMVRFZUGP-WOOVXOMTSA-N

InChi Code: InChI=1S/C24H25ClN2O/c1-15-3-5-16(6-4-15)20-13-19-11-12-22(27(19)2)24(20)23-14-21(26-28-23)17-7-9-18(25)10-8-17/h3-10,14,19-20,22,24H,11-13H2,1-2H3/t19-,20-,22+,24+/m1/s1

SMILES Code: [H][C@@]12[C@@H](C3=CC(C4=CC=C(Cl)C=C4)=NO3)[C@@H](C5=CC=C(C)C=C5)C[C@@](CC1)(N2C)[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 392.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Navarro HA, Howard JL, Pollard GT, Carroll FI. Positive allosteric modulation of the human cannabinoid (CB) receptor by RTI-371, a selective inhibitor of the dopamine transporter. Br J Pharmacol. 2009 Apr;156(7):1178-84. doi: 10.1111/j.1476-5381.2009.00124.x. PubMed PMID: 19226282; PubMed Central PMCID: PMC2697692.

2: Hiranita T, Wilkinson DS, Hong WC, Zou MF, Kopajtic TA, Soto PL, Lupica CR, Newman AH, Katz JL. 2-isoxazol-3-phenyltropane derivatives of cocaine: molecular and atypical system effects at the dopamine transporter. J Pharmacol Exp Ther. 2014 May;349(2):297-309. doi: 10.1124/jpet.113.212738. Erratum in: J Pharmacol Exp Ther. 2014 Jun 1;349(3):534. PubMed PMID: 24518035; PubMed Central PMCID: PMC3989806.

3: Carroll FI, Pawlush N, Kuhar MJ, Pollard GT, Howard JL. Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes. J Med Chem. 2004 Jan 15;47(2):296-302. PubMed PMID: 14711303.