WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530475
Description: IHVR-11029 is a potent ER α-glucosidase inhibitor. IHVR-11029 is active against multiple hemorrhagic fever viruses. IHVR-11029 efficiently disrupts the morphogenesis of a broad spectrum of enveloped viruses.
MedKoo Cat#: 530475
Chemical Formula: C18H27F2NO5
Exact Mass: 375.1857
Molecular Weight: 375.4128
Elemental Analysis: C, 57.59; H, 7.25; F, 10.12; N, 3.73; O, 21.31
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: IHVR-11029; IHVR 11029; IHVR11029.
IUPAC/Chemical Name: (2R,3R,4R,5S)-1-(6-(2,5-difluorophenoxy)hexyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
InChi Key: XGCVJVFPIXDHPA-CYGHRXIMSA-N
InChi Code: InChI=1S/C18H27F2NO5/c19-12-5-6-13(20)16(9-12)26-8-4-2-1-3-7-21-10-15(23)18(25)17(24)14(21)11-22/h5-6,9,14-15,17-18,22-25H,1-4,7-8,10-11H2/t14-,15+,17-,18-/m1/s1
SMILES Code: OC[C@@H]1[C@H]([C@@H]([C@H](CN1CCCCCCOC2=CC(F)=CC=C2F)O)O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 375.4128 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Zhao X, Guo F, Comunale MA, Mehta A, Sehgal M, Jain P, Cuconati A, Lin H,
Block TM, Chang J, Guo JT. Inhibition of endoplasmic reticulum-resident
glucosidases impairs severe acute respiratory syndrome coronavirus and human
coronavirus NL63 spike protein-mediated entry by altering the glycan processing
of angiotensin I-converting enzyme 2. Antimicrob Agents Chemother. 2015
Jan;59(1):206-16. doi: 10.1128/AAC.03999-14. PubMed PMID: 25348530; PubMed
Central PMCID: PMC4291352.
2: Chang J, Warren TK, Zhao X, Gill T, Guo F, Wang L, Comunale MA, Du Y, Alonzi
DS, Yu W, Ye H, Liu F, Guo JT, Mehta A, Cuconati A, Butters TD, Bavari S, Xu X,
Block TM. Small molecule inhibitors of ER α-glucosidases are active against
multiple hemorrhagic fever viruses. Antiviral Res. 2013 Jun;98(3):432-40. doi:
10.1016/j.antiviral.2013.03.023. PubMed PMID: 23578725; PubMed Central PMCID: