Guanoclor
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MedKoo CAT#: 329525

CAS#: 5001-32-1

Description: Guanoclor is an antihypertensive drug.


Price and Availability

Size Price Shipping out time Quantity
1g USD 1650 2 Weeks
2g USD 2950 2 Weeks
5g USD 4250 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-26. Prices are subject to change without notice.

Guanoclor, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 329525
Name: Guanoclor
CAS#: 5001-32-1
Chemical Formula: C9H12Cl2N4O
Exact Mass: 262.0388
Molecular Weight: 263.122
Elemental Analysis: C, 41.08; H, 4.60; Cl, 26.95; N, 21.29; O, 6.08


Synonym: Guanoclor; VATENSOL.

IUPAC/Chemical Name: 2-(2-(2,6-dichlorophenoxy)ethyl)hydrazine-1-carboximidamide

InChi Key: XIHXRRMCNSMUET-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H12Cl2N4O/c10-6-2-1-3-7(11)8(6)16-5-4-14-15-9(12)13/h1-3,14H,4-5H2,(H4,12,13,15)

SMILES Code: N=C(NNCCOC1=C(Cl)C=CC=C1Cl)N


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: SINNIAH R, GATENBY PB. CLINICOPHARMACOLOGICAL ASSESSMENT OF THE NEW ANTI-HYPERTENSIVE COMPOUND GUANOCLOR (VATENSOL). Ir J Med Sci. 1965 Mar;471:111-24. PubMed PMID: 14295356.

2: BENDER S. TO-DAY'S DRUGS. GUANOCLOR. Br Med J. 1964 Jul 25;2(5403):238-9. PubMed PMID: 14150915; PubMed Central PMCID: PMC1817852.

3: Mackinnon J, el-Baz LM. A comparison of guanoclor and methyldopa in the treatment of severe hypertension. Br J Clin Pract. 1971 Mar;25(3):135-7. PubMed PMID: 4929159.

4: Mehta AB, Biswas AK, Pinto IJ, Sheth UK. Clinical assessment of the new antihypertensive Compound--1029 (Vatensol)--Guanoclor. Indian Heart J. 1967 Oct;19(4):322-8. PubMed PMID: 4870898.

5: Lawrie TD. Current therapeutics CXXXV.--Guanoclor. Practitioner. 1967 Aug;199(190):239-43. PubMed PMID: 6058648.

6: Hodge JV. Guanoclor as an antihypertensive drug. Br Med J. 1966 Oct 22;2(5520):981-4. PubMed PMID: 5921741; PubMed Central PMCID: PMC1944426.

7: Wahbi AA, Bedair MM, Galal SM, Gazy AA. Spectrophotometric analysis of some guanidino drugs by acid-dye and charge-transfer complexation methods. J Pharm Biomed Anal. 1993 Aug;11(8):639-45. PubMed PMID: 8257728.

8: Frelin C, Vigne P, Barbry P, Lazdunski M. Interaction of guanidinium and guanidinium derivatives with the Na+/H+ exchange system. Eur J Biochem. 1986 Jan 15;154(2):241-5. PubMed PMID: 3002793.

9: Vigne P, Lazdunski M, Frelin C. Guanabenz, guanochlor, guanoxan and idazoxan bind with high affinity to non-adrenergic sites in pig kidney membranes. Eur J Pharmacol. 1989 Jan 31;160(2):295-8. PubMed PMID: 2527160.

10: LAWRIE TD, LORIMER AR, MCALPINE SG, REINERT H. CLINICAL TRIAL AND PHARMACOLOGICAL STUDY OF COMPOUND 1029. ("VATENSOL"). Br Med J. 1964 Feb 15;1(5380):402-6. PubMed PMID: 14085968; PubMed Central PMCID: PMC1813383.

11: Ham NS. Conformational populations for antihistamines and antihypertensives in solution. J Pharm Sci. 1976 Apr;65(4):612-4. PubMed PMID: 5591.