Azoramide
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MedKoo CAT#: 329524

CAS#: 932986-18-0

Description: Azoramide is a small-molecule modulator of the unfolded protein response with antidiabetic activity. Azoramide mproves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress in multiple systems. Azoramide also exhibited potent antidiabetic efficacy in two independent mouse models of obesity by improving insulin sensitivity and pancreatic β cell function. Azoramide can be potential drug candidate for type 2 diabetes.


Price and Availability

Size Price Shipping out time Quantity
25mg USD 120 Same Day
50mg USD 190 Same Day
100mg USD 350 Same Day
200mg USD 550 Same Day
500mg USD 950 Same Day
1g USD 1750 Same Day
2g USD 2850 2 Weeks
5g USD 5450 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-28. Prices are subject to change without notice.

Azoramide, purity > 98%, is in stock. . The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 329524
Name: Azoramide
CAS#: 932986-18-0
Chemical Formula: C15H17ClN2OS
Exact Mass: 308.075
Molecular Weight: 308.824
Elemental Analysis: C, 58.34; H, 5.55; Cl, 11.48; N, 9.07; O, 5.18; S, 10.38


Synonym: Azoramide

IUPAC/Chemical Name: N-[2-[2-(4-chlorophenyl)-4-thiazolyl]ethyl]-butanamide

InChi Key: VYBFWKKCWTXCQX-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H17ClN2OS/c1-2-3-14(19)17-9-8-13-10-20-15(18-13)11-4-6-12(16)7-5-11/h4-7,10H,2-3,8-9H2,1H3,(H,17,19)

SMILES Code: CCCC(NCCC1=CSC(C2=CC=C(Cl)C=C2)=N1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Fu S, Yalcin A, Lee GY, Li P, Fan J, Arruda AP, Pers BM, Yilmaz M, Eguchi K,
Hotamisligil GS. Phenotypic assays identify azoramide as a small-molecule
modulator of the unfolded protein response with antidiabetic activity. Sci Transl
Med. 2015 Jun 17;7(292):292ra98. doi: 10.1126/scitranslmed.aaa9134. PubMed PMID:
26084805; PubMed Central PMCID: PMC5063051.

2: Guillen C. Azoramide: a new drug for the treatment of type 2 diabetes? Ann
Transl Med. 2016 Oct;4(Suppl 1):S45. PubMed PMID: 27868013.