WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 329524
Description: Azoramide is a small-molecule modulator of the unfolded protein response with antidiabetic activity. Azoramide mproves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress in multiple systems. Azoramide also exhibited potent antidiabetic efficacy in two independent mouse models of obesity by improving insulin sensitivity and pancreatic β cell function. Azoramide can be potential drug candidate for type 2 diabetes.
MedKoo Cat#: 329524
Chemical Formula: C15H17ClN2OS
Exact Mass: 308.075
Molecular Weight: 308.824
Elemental Analysis: C, 58.34; H, 5.55; Cl, 11.48; N, 9.07; O, 5.18; S, 10.38
IUPAC/Chemical Name: N-[2-[2-(4-chlorophenyl)-4-thiazolyl]ethyl]-butanamide
InChi Key: VYBFWKKCWTXCQX-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H17ClN2OS/c1-2-3-14(19)17-9-8-13-10-20-15(18-13)11-4-6-12(16)7-5-11/h4-7,10H,2-3,8-9H2,1H3,(H,17,19)
SMILES Code: CCCC(NCCC1=CSC(C2=CC=C(Cl)C=C2)=N1)=O
1: Fu S, Yalcin A, Lee GY, Li P, Fan J, Arruda AP, Pers BM, Yilmaz M, Eguchi K,
Hotamisligil GS. Phenotypic assays identify azoramide as a small-molecule
modulator of the unfolded protein response with antidiabetic activity. Sci Transl
Med. 2015 Jun 17;7(292):292ra98. doi: 10.1126/scitranslmed.aaa9134. PubMed PMID:
26084805; PubMed Central PMCID: PMC5063051.
2: Guillen C. Azoramide: a new drug for the treatment of type 2 diabetes? Ann
Transl Med. 2016 Oct;4(Suppl 1):S45. PubMed PMID: 27868013.