AMG-47a
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MedKoo CAT#: 407353

CAS#: 882663-88-9

Description: AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.

Chemical Structure

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AMG-47a
CAS# 882663-88-9
Instruction

Theoretical Analysis

MedKoo Cat#: 407353
Name: AMG-47a
CAS#: 882663-88-9
Chemical Formula: C29H28F3N5O2
Exact Mass: 535.22
Molecular Weight: 535.571
Elemental Analysis: C, 65.04; H, 5.27; F, 10.64; N, 13.08; O, 5.97

Price and Availability

Size Price Availability Quantity
5mg USD 315 2 Weeks
10mg USD 550 2 Weeks
25mg USD 850 2 Weeks
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Synonym: AMG-47a; AMG 47a; AMG47a; AMG-47; AMG 47; AMG47.

IUPAC/Chemical Name: 4-methyl-3-[2-(2-morpholin-4-ylethylamino)quinazolin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzamide

InChi Key: DVRSTRMZTAPMKO-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H28F3N5O2/c1-19-5-6-21(27(38)35-24-4-2-3-23(17-24)29(30,31)32)16-25(19)20-7-8-26-22(15-20)18-34-28(36-26)33-9-10-37-11-13-39-14-12-37/h2-8,15-18H,9-14H2,1H3,(H,35,38)(H,33,34,36)

SMILES Code: O=C(NC1=CC=CC(C(F)(F)F)=C1)C2=CC=C(C)C(C3=CC4=CN=C(NCCN5CCOCC5)N=C4C=C3)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 535.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Carver J, Dexheimer TS, Hsu D, Weng MT, Smith JL, Guha R, Jadhav A, Simeonov
A, Luo J. A high-throughput assay for small molecule destabilizers of the KRAS
oncoprotein. PLoS One. 2014 Aug 5;9(8):e103836. doi:
10.1371/journal.pone.0103836. PubMed PMID: 25093678; PubMed Central PMCID:
PMC4122376.