AMG-47a
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407353

CAS#: 882663-88-9

Description: AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.


Chemical Structure

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AMG-47a
CAS# 882663-88-9

Theoretical Analysis

MedKoo Cat#: 407353
Name: AMG-47a
CAS#: 882663-88-9
Chemical Formula: C29H28F3N5O2
Exact Mass: 535.2195
Molecular Weight: 535.5712
Elemental Analysis: C, 65.04; H, 5.27; F, 10.64; N, 13.08; O, 5.97

Price and Availability

Size Price Availability Quantity
100.0mg USD 750.0 2 Weeks
200.0mg USD 1250.0 2 Weeks
500.0mg USD 1950.0 2 Weeks
1.0g USD 3250.0 2 Weeks
2.0g USD 4150.0 2 Weeks
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Synonym: AMG-47a; AMG 47a; AMG47a; AMG-47; AMG 47; AMG47.

IUPAC/Chemical Name: 4-methyl-3-[2-(2-morpholin-4-ylethylamino)quinazolin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzamide

InChi Key: DVRSTRMZTAPMKO-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H28F3N5O2/c1-19-5-6-21(27(38)35-24-4-2-3-23(17-24)29(30,31)32)16-25(19)20-7-8-26-22(15-20)18-34-28(36-26)33-9-10-37-11-13-39-14-12-37/h2-8,15-18H,9-14H2,1H3,(H,35,38)(H,33,34,36)

SMILES Code: O=C(NC1=CC=CC(C(F)(F)F)=C1)C2=CC=C(C)C(C3=CC4=CN=C(NCCN5CCOCC5)N=C4C=C3)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 535.5712 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Carver J, Dexheimer TS, Hsu D, Weng MT, Smith JL, Guha R, Jadhav A, Simeonov
A, Luo J. A high-throughput assay for small molecule destabilizers of the KRAS
oncoprotein. PLoS One. 2014 Aug 5;9(8):e103836. doi:
10.1371/journal.pone.0103836. PubMed PMID: 25093678; PubMed Central PMCID:
PMC4122376.

AMG-47a

100.0mg / USD 750.0