WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530395
CAS#: 328998-25-0
Description: 4E1RCat is an inhibitor of the eIF4F translation initiation complex that blocks eIF4E:eIF4G and eIF4E:4E-BP1 interactions.
MedKoo Cat#: 530395
Name: 4E1RCat
CAS#: 328998-25-0
Chemical Formula: C28H18N2O6
Exact Mass: 478.1165
Molecular Weight: 478.46
Elemental Analysis: C, 70.29; H, 3.79; N, 5.86; O, 20.06
Synonym: 4E1RCat; eIF4E/eIF4G Interaction Inhibitor II.
IUPAC/Chemical Name: (Z)-4-(3-((5-(4-nitrophenyl)furan-2-yl)methylene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid
InChi Key: BBQRBOIMSKMFFO-PGMHBOJBSA-N
InChi Code: InChI=1S/C28H18N2O6/c31-27-21(16-24-14-15-26(36-24)19-6-12-23(13-7-19)30(34)35)17-25(18-4-2-1-3-5-18)29(27)22-10-8-20(9-11-22)28(32)33/h1-17H,(H,32,33)/b21-16-
SMILES Code: O=C1/C(C=C(C2=CC=CC=C2)N1C3=CC=C(C(O)=O)C=C3)=C\C4=CC=C(C5=CC=C([N+]([O-])=O)C=C5)O4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 478.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Shuda M, Velásquez C, Cheng E, Cordek DG, Kwun HJ, Chang Y, Moore PS. CDK1
substitutes for mTOR kinase to activate mitotic cap-dependent protein
translation. Proc Natl Acad Sci U S A. 2015 May 12;112(19):5875-82. doi:
10.1073/pnas.1505787112. PubMed PMID: 25883264; PubMed Central PMCID: PMC4434708.
2: Arnold N, Koppula PR, Gul R, Luck C, Pulakat L. Regulation of cardiac
expression of the diabetic marker microRNA miR-29. PLoS One. 2014 Jul
25;9(7):e103284. doi: 10.1371/journal.pone.0103284. PubMed PMID: 25062042; PubMed
Central PMCID: PMC4111545.
