4E1RCat
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530395

CAS#: 328998-25-0

Description: 4E1RCat is an inhibitor of the eIF4F translation initiation complex that blocks eIF4E:eIF4G and eIF4E:4E-BP1 interactions.


Chemical Structure

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4E1RCat
CAS# 328998-25-0

Theoretical Analysis

MedKoo Cat#: 530395
Name: 4E1RCat
CAS#: 328998-25-0
Chemical Formula: C28H18N2O6
Exact Mass: 478.1165
Molecular Weight: 478.46
Elemental Analysis: C, 70.29; H, 3.79; N, 5.86; O, 20.06

Price and Availability

Size Price Availability Quantity
25.0mg USD 150.0 Same Day
50.0mg USD 250.0 Same Day
100.0mg USD 450.0 Same Day
200.0mg USD 750.0 Same Day
500.0mg USD 1550.0 Same Day
1.0g USD 2650.0 2 Weeks
2.0g USD 4250.0 2 Weeks
5.0g USD 6850.0 2 Weeks
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Synonym: 4E1RCat; eIF4E/eIF4G Interaction Inhibitor II.

IUPAC/Chemical Name: (Z)-4-(3-((5-(4-nitrophenyl)furan-2-yl)methylene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid

InChi Key: BBQRBOIMSKMFFO-PGMHBOJBSA-N

InChi Code: InChI=1S/C28H18N2O6/c31-27-21(16-24-14-15-26(36-24)19-6-12-23(13-7-19)30(34)35)17-25(18-4-2-1-3-5-18)29(27)22-10-8-20(9-11-22)28(32)33/h1-17H,(H,32,33)/b21-16-

SMILES Code: O=C1/C(C=C(C2=CC=CC=C2)N1C3=CC=C(C(O)=O)C=C3)=C\C4=CC=C(C5=CC=C([N+]([O-])=O)C=C5)O4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 478.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Shuda M, Velásquez C, Cheng E, Cordek DG, Kwun HJ, Chang Y, Moore PS. CDK1
substitutes for mTOR kinase to activate mitotic cap-dependent protein
translation. Proc Natl Acad Sci U S A. 2015 May 12;112(19):5875-82. doi:
10.1073/pnas.1505787112. PubMed PMID: 25883264; PubMed Central PMCID: PMC4434708.

2: Arnold N, Koppula PR, Gul R, Luck C, Pulakat L. Regulation of cardiac
expression of the diabetic marker microRNA miR-29. PLoS One. 2014 Jul
25;9(7):e103284. doi: 10.1371/journal.pone.0103284. PubMed PMID: 25062042; PubMed
Central PMCID: PMC4111545.

4E1RCat

25.0mg / USD 150.0