NZ-419

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530022

CAS#: 84210-26-4

Description: NZ-419, also known as HD003, is an antioxidant potentially for the treatment of renal failure.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-09-20. Prices are subject to change without notice.

NZ-419 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530022
Name: NZ-419
CAS#: 84210-26-4
Chemical Formula: C4H6N2O2
Exact Mass: 114.04
Molecular Weight: 114.1
Elemental Analysis: C, 42.11; H, 5.30; N, 24.55; O, 28.04


Synonym: NZ-419; HD-003; NZ 419; HD 003; NZ419; HD003

IUPAC/Chemical Name: 1-methylimidazolidine-2,4-dione

InChi Key: RHYBFKMFHLPQPH-UHFFFAOYSA-N

InChi Code: InChI=1S/C4H6N2O2/c1-6-2-3(7)5-4(6)8/h2H2,1H3,(H,5,7,8)

SMILES Code: O=C1NC(CN1C)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Ienaga K, Sohn M, Naiki M, Jaffa AA. Creatinine metabolite, HMH (5-hydroxy-1-methylhydantoin; NZ-419), modulates bradykinin-induced changes in vascular smooth muscle cells. J Recept Signal Transduct Res. 2014 Jun;34(3):195-200. doi: 10.3109/10799893.2013.876039. PubMed PMID: 24641698.

2: Ienaga K, Park CH, Yokozawa T. Protective effect of an intrinsic antioxidant, HMH (5-hydroxy-1-methylhydantoin; NZ-419), against cellular damage of kidney tubules. Exp Toxicol Pathol. 2013 Jul;65(5):559-66. doi: 10.1016/j.etp.2012.05.001. PubMed PMID: 22749566.

3: Ienaga K, Yokozawa T. Creatinine and HMH (5-hydroxy-1-methylhydantoin, NZ-419) as intrinsic hydroxyl radical scavengers. Drug Discov Ther. 2011 Aug;5(4):162-75. PubMed PMID: 22466296.

4: Hasegawa G, Nakano K, Ienaga K. Serum accumulation of a creatinine oxidative metabolite (NZ-419: 5-hydroxy-1- methylhydatoin) as an intrinsic antioxidant in diabetic patients with or without chronic kidney disease. Clin Nephrol. 2011 Oct;76(4):284-9. PubMed PMID: 21955863.

5: Ienaga K, Yokozawa T. Treatment with NZ-419 (5-Hydroxy-1-methylimidazoline-2,4-dione), a novel intrinsic antioxidant, against the progression of chronic kidney disease at stages 3 and 4 in rats. Biol Pharm Bull. 2010;33(5):809-15. PubMed PMID: 20460759.

6: Ienaga K, Mikami H, Yokozawa T. First indications demonstrating the preventive effects of NZ-419, a novel intrinsic antioxidant, on the initiation and/or progression of chronic renal failure in rats. Biol Pharm Bull. 2009 Jul;32(7):1204-8. PubMed PMID: 19571386.

7: Gao L, Yang S, Liu J, Liu L. [Preventive effects of 5-hydroxy-1-methylhydantoin on paraquat-induced nephrotoxicity in rat]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Apr;27(4):246-9. doi: 10.3760/cma.j.issn.2095-4352.2015.04.004. Chinese. PubMed PMID: 25891451.

8: Ienaga K, Nakamura K, Naka F, Goto T. The metabolism of 1-methylhydantoin via 5-hydroxy-1-methylhydantoin in mammals. Biochim Biophys Acta. 1988 Dec 15;967(3):441-3. PubMed PMID: 3196760.

9: Nakamura K, Ienaga K. Creatol (5-hydroxycreatinine), a new toxin candidate in uremic patients. Experientia. 1990 May 15;46(5):470-2. PubMed PMID: 2347396.