WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531444

CAS#: 202463-68-1

Description: AM281 is a synthetic cannabinoid CB1 receptor antagonist.

Chemical Structure

CAS# 202463-68-1

Theoretical Analysis

MedKoo Cat#: 531444
Name: AM281
CAS#: 202463-68-1
Chemical Formula: C21H19Cl2IN4O2
Exact Mass: 555.993
Molecular Weight: 557.2135
Elemental Analysis: C, 45.27; H, 3.44; Cl, 12.72; I, 22.77; N, 10.06; O, 5.74

Price and Availability

Size Price Availability Quantity
1.0mg USD 205.0 2 Weeks
5.0mg USD 360.0 2 Weeks
10.0mg USD 575.0 2 Weeks
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Synonym: AM281; AM 281; AM-281

IUPAC/Chemical Name: 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholin-4-ylpyrazole-3-carboxamide


InChi Code: InChI=1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 557.2135 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Sidibeh CO, Pereira MJ, Lau Börjesson J, Kamble PG, Skrtic S, Katsogiannos P, Sundbom M, Svensson MK, Eriksson JW. Role of cannabinoid receptor 1 in human adipose tissue for lipolysis regulation and insulin resistance. Endocrine. 2016 Nov 17. [Epub ahead of print] PubMed PMID: 27858284.

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6: Botanas CJ, de la Peña JB, Dela Pena IJ, Tampus R, Kim HJ, Yoon SS, Seo JW, Jeong EJ, Cheong JH. Evaluation of the abuse potential of AM281, a new synthetic cannabinoid CB1 receptor antagonist. Eur J Pharmacol. 2015 Nov 5;766:135-41. doi: 10.1016/j.ejphar.2015.10.004. PubMed PMID: 26450088.

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14: Lisboa SF, Gomes FV, Silva AL, Uliana DL, Camargo LH, Guimarães FS, Cunha FQ, Joca SR, Resstel LB. Increased Contextual Fear Conditioning in iNOS Knockout Mice: Additional Evidence for the Involvement of Nitric Oxide in Stress-Related Disorders and Contribution of the Endocannabinoid System. Int J Neuropsychopharmacol. 2015 Jan 24;18(8). pii: pyv005. doi: 10.1093/ijnp/pyv005. PubMed PMID: 25618404; PubMed Central PMCID: PMC4571624.

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20: Gasperi V, Evangelista D, Oddi S, Florenzano F, Chiurchiù V, Avigliano L, Catani MV, Maccarrone M. Regulation of inflammation and proliferation of human bladder carcinoma cells by type-1 and type-2 cannabinoid receptors. Life Sci. 2015 Oct 1;138:41-51. doi: 10.1016/j.lfs.2014.09.031. PubMed PMID: 25445433.


1.0mg / USD 205.0